Molecular structure of L-Quisqualic acid, CAS Number: 52809-07-1
L-Quisqualic acid (CAS 52809-07-1)
Application:
L-Quisqualic acid is an agonist for group I mGluR
CAS Number:
52809-07-1
Purity:
≥99% (free from glutamate)
Molecular Weight:
189.1
Molecular Formula:
C5H7N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-Quisqualic acid acts as an agonist for mGluR-1 (metabotropic glutamate receptor 1), and can be used to differentiate between mGluR-1 and mGluR-4. It has been reported to induce a slow K(+)-current response in B6 neurons of Aplysia buccal ganglia. It may act to inhibit human PSM (glutamate carboxypeptidase II, GCPII), an enzyme of the central nervous system and the human prostate. It has also been shown to increase the release of acetylcholine from the rat hippocampus and striatum. L-Quisqualic acid is an activator of GluR.
L-Quisqualic acid (CAS 52809-07-1) References
- Direct radiolabeling by [3H]quisqualic acid of group I metabotropic glutamate receptor in rat brain synaptic membranes. | Hinoi, E., et al. 2000. Brain Res. 881: 199-203. PMID: 11036159
- Chlormethiazole inhibits epileptiform activity by potentiating GABA(A) receptor function. | Empson, RM., et al. 2000. Brain Res. 884: 31-4. PMID: 11082484
- L-Quisqualic acid transport into hippocampal neurons by a cystine-sensitive carrier is required for the induction of quisqualate sensitization. | Chase, LA., et al. 2001. Neuroscience. 106: 287-301. PMID: 11566501
- The non-competitive AMPA receptor antagonist (GYKI 52466) blocks quisqualate-induced acetylcholine release from the rat hippocampus and striatum: an in vivo microdialysis study. | Rakovska, A., et al. 2002. Neurochem Int. 40: 419-26. PMID: 11821149
- Structure-function relationships for analogues of L-2-amino-4-phosphonobutanoic acid on the quisqualic acid-sensitive AP4 receptor of the rat hippocampus. | Schulte, MK., et al. 1992. Brain Res. 582: 291-8. PMID: 1327404
- Quisqualic acid analogues: synthesis of beta-heterocyclic 2-aminopropanoic acid derivatives and their activity at a novel quisqualate-sensitized site. | Subasinghe, N., et al. 1992. J Med Chem. 35: 4602-7. PMID: 1469691
- Analogues of homoibotenic acid show potent and selective activity following sensitisation by quisqualic acid. | Vestergaard, HT., et al. 2004. Eur J Pharmacol. 488: 101-9. PMID: 15044041
- Mutation-induced quisqualic acid and ibotenic acid affinity at the metabotropic glutamate receptor subtype 4: ligand selectivity results from a synergy of several amino acid residues. | Hermit, MB., et al. 2004. J Biol Chem. 279: 34811-7. PMID: 15184361
- The lathyrus toxin, beta-N-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP), and homocysteic acid sensitize CA1 pyramidal neurons to cystine and L-2-amino-6-phosphonohexanoic acid. | Chase, LA., et al. 2007. Toxicol Appl Pharmacol. 219: 1-9. PMID: 17234231
- Regulatory roles of Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 2A on the quisqualic acid-induced K+-current response in identified neurons of Aplysia. | Kimura, S., et al. 2008. Neurosci Res. 60: 73-81. PMID: 17980450
- Rare excitatory amino acid from flowers of zonal geranium responsible for paralyzing the Japanese beetle. | Ranger, CM., et al. 2011. Proc Natl Acad Sci U S A. 108: 1217-21. PMID: 21205899
- Effects of glutamic acid analogues on identifiable giant neurones, sensitive to beta-hydroxy-L-glutamic acid, of an African giant snail (Achatina fulica Férussac). | Nakajima, T., et al. 1985. Br J Pharmacol. 86: 645-54. PMID: 2866005
- The action of natural and synthetic isomers of quisqualic acid at a well-defined glutamatergic synapse. | Boden, P., et al. 1986. Brain Res. 385: 205-11. PMID: 3022871
- Synthesis of oxadiazolidinedione derivatives as quisqualic acid analogues and their evaluation at a quisqualate-sensitized site in the rat hippocampus. | Venkatraman, S., et al. 1994. J Med Chem. 37: 3939-46. PMID: 7966155
- Quisqualic acid induced sensitization and the active uptake of L-quisqualic acid by hippocampal slices. | Schulte, MK., et al. 1993. Brain Res. 605: 85-92. PMID: 8096790
- Characterization of metabotropic glutamate receptors in rat C6 glioma cells. | Albasanz, JL., et al. 1997. Eur J Pharmacol. 326: 85-91. PMID: 9178659
Inhibitor of:
PSM.Activator of:
GluR, and mGluR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Quisqualic acid, 5 mg | sc-200467 | 5 mg | $306.00 | |||
L-Quisqualic acid, 25 mg | sc-200467A | 25 mg | $1479.00 |