Date published: 2026-5-21

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L-Proline t-butyl ester (CAS 2812-46-6)

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Alternate Names:
H-L-Pro-OtBu
CAS Number:
2812-46-6
Molecular Weight:
171.2
Molecular Formula:
C9H17NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-Proline t-butyl ester is a compound that functions as a protecting group for the carboxyl group of proline in peptide synthesis. It is used to prevent unwanted side reactions during peptide bond formation, allowing for the selective deprotection of the carboxyl group at a later stage. L-Proline T-Butyl Ester acts by forming a stable, temporary derivative of the carboxyl group, which can be easily removed under mild conditions without affecting other functional groups in the peptide chain. L-Proline t-butyl ester plays a role in facilitating the efficient and selective synthesis of complex peptides by protecting the carboxyl group of proline, thereby enabling the precise assembly of peptide sequences. Its mechanism of action involves the reversible formation of a stable derivative, which allows for the manipulation of the peptide chain without altering the integrity of the molecule.


L-Proline t-butyl ester (CAS 2812-46-6) References

  1. Remote chirality transfer in nucleophilic catalysis with N-(4-pyridinyl)-L-proline derivatives.  |  Kawabata, T., et al. 2003. Chirality. 15: 71-6. PMID: 12467046
  2. Interaction of a chirally functionalised porphyrin derivative with chiral micellar aggregates.  |  Monti, D., et al. 2004. Chem Commun (Camb). 972-3. PMID: 15069500
  3. Photogenerated quinone methides as useful intermediates in the synthesis of chiral BINOL ligands.  |  Colloredo-Mels, S., et al. 2006. J Org Chem. 71: 3889-95. PMID: 16674065
  4. BINOL-amino acid conjugates as triggerable carriers of DNA-targeted potent photocytotoxic agents.  |  Doria, F., et al. 2007. J Med Chem. 50: 6570-9. PMID: 18047263
  5. Recent Advances in Substrate-Controlled Asymmetric Induction Derived from Chiral Pool α-Amino Acids for Natural Product Synthesis.  |  Paek, SM., et al. 2016. Molecules. 21: PMID: 27455209
  6. Evaluation of the equilibrium and activation parameters for the interconversion of the conformational isomers of some N-acylprolines by nuclear magnetic resonance spectroscopy  |  Hernani L. Maia, Keith G. Orrell and H. N. Rydon . 1976. J. Chem. Soc., Perkin Trans. 2: 761-763.
  7. A novel oxazine from the condensation of chloroanthraquinone and t-butyl L-prolinate  |  Ernesto Abel, Ian M. McRobbie & George W. Gokel. 1998. Journal of Chemical Crystallography. 28: 47–51.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-Proline t-butyl ester, 1 g

sc-295324
1 g
$71.00

L-Proline t-butyl ester, 5 g

sc-295324A
5 g
$153.00