Date published: 2025-11-3

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L-(+)-Ergothioneine-d9 (CAS 497-30-3 (unlabeled))

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Alternate Names:
(αS)-α-Carboxy-2,3-dihydro-N,N,N-tri(methyl-d3)-2-thioxo-1H-imidazole-4-ethanaminium Inner Salt; 2-Mercaptohistidine Betaine-d9
CAS Number:
497-30-3 (unlabeled)
Molecular Weight:
238.35
Molecular Formula:
C9H6D9N3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-(+)-Ergothioneine-d9 is a deuterated derivative of ergothioneine, a naturally occurring amino acid known for its high antioxidant activity and presence in various fungal species and certain bacteria. This modified version, where nine of the hydrogen atoms are replaced with the heavier isotope deuterium, is primarily used in scientific research to explore the metabolic pathways and bioavailability of ergothioneine. By incorporating deuterium, researchers can trace the compound′s movement and transformation within biological systems with greater accuracy, without altering its chemical nature. This method enhances the understanding of ergothioneine′s role in protecting cells against oxidative stress and damage, facilitating detailed studies on its biochemical behavior and interactions in different environments. This enhanced understanding helps in elucidating the complex mechanisms by which ergothioneine exerts its effects at the cellular level, contributing valuable insights into its potential applications in various fields of biochemical and environmental research.


L-(+)-Ergothioneine-d9 (CAS 497-30-3 (unlabeled)) References

  1. Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4).  |  Nakamura, T., et al. 2008. Biol Pharm Bull. 31: 1580-4. PMID: 18670092
  2. Quantification of L-ergothioneine in human plasma and erythrocytes by liquid chromatography-tandem mass spectrometry.  |  Wang, LZ., et al. 2013. J Mass Spectrom. 48: 406-12. PMID: 23494799
  3. Organic cation transporter-mediated ergothioneine uptake in mouse neural progenitor cells suppresses proliferation and promotes differentiation into neurons.  |  Ishimoto, T., et al. 2014. PLoS One. 9: e89434. PMID: 24586778
  4. Liver ergothioneine accumulation in a guinea pig model of non-alcoholic fatty liver disease. A possible mechanism of defence?  |  Cheah, IK., et al. 2016. Free Radic Res. 50: 14-25. PMID: 26634964
  5. Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues.  |  Tang, RMY., et al. 2018. Sci Rep. 8: 1601. PMID: 29371632
  6. The proteobacterial species Burkholderia pseudomallei produces ergothioneine, which enhances virulence in mammalian infection.  |  Gamage, AM., et al. 2018. FASEB J. fj201800716. PMID: 29890088

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-(+)-Ergothioneine-d9, 1 mg

sc-497633
1 mg
$370.00

L-(+)-Ergothioneine-d9, 10 mg

sc-497633A
10 mg
$2530.00