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L-Phenylalanine (CAS 63-91-2)

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Alternate Names:
(S)-2-Amino-3-phenylpropionic acid
Application:
L-Phenylalanine is an essential amino acid
CAS Number:
63-91-2
Molecular Weight:
165.19
Molecular Formula:
C9H11NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-Phenylalanine stands as an essential amino acid, pivotal in the intricate biochemical pathways that govern neurotransmitter synthesis and metabolic processes within living organisms. Its biological transformation into L-tyrosine, a subsequent DNA-encoded amino acid, sets the stage for a series of enzymatic reactions that lead to the production of critical neurotransmitters such as dopamine, norepinephrine, and epinephrine. These neurotransmitters play key roles in regulating mood, alertness, and the body′s response to stress. The metabolic journey from L-Phenylalanine to these neurotransmitters underscores the complex interplay between nutrition and neurochemical balance, highlighting the amino acid′s significance beyond its primary structural role in proteins.


L-Phenylalanine (CAS 63-91-2) References

  1. Uptake of L-leucine and L-phenylalanine across the basolateral cell surface in isolated oxyntic glands.  |  Sobrevía, L., et al. 1992. Biochim Biophys Acta. 1106: 257-63. PMID: 1596506
  2. Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria.  |  Singh, V., et al. 2014. Sci Rep. 4: 3875. PMID: 24464217
  3. The polymorphs of L-phenylalanine.  |  Ihlefeldt, FS., et al. 2014. Angew Chem Int Ed Engl. 53: 13600-4. PMID: 25336255
  4. Reduction of L-phenylalanine in protein hydrolysates using L-phenylalanine ammonia-lyase from Rhodosporidium toruloides.  |  Castañeda, MT., et al. 2015. J Ind Microbiol Biotechnol. 42: 1299-307. PMID: 26243390
  5. Enhancement of  l-phenylalanine production in Escherichia coli by heterologous expression of Vitreoscilla hemoglobin.  |  Wu, WB., et al. 2018. Biotechnol Appl Biochem. 65: 476-483. PMID: 28872702
  6. An alternative pathway for the formation of aromatic aroma compounds derived from l-phenylalanine via phenylpyruvic acid in tea (Camellia sinensis (L.) O. Kuntze) leaves.  |  Wang, X., et al. 2019. Food Chem. 270: 17-24. PMID: 30174031
  7. Transport of L-phenylalanine and related amino acids at the ovine blood-brain barrier.  |  Brenton, DP. and Gardiner, RM. 1988. J Physiol. 402: 497-514. PMID: 3236248
  8. L-phenylalanine attenuates high salt-induced hypertension in Dahl SS rats through activation of GCH1-BH4.  |  Wang, Z., et al. 2021. PLoS One. 16: e0250126. PMID: 33857222
  9. Enzymatic determination of L-phenylalanine and phenylpyruvate with L-phenylalanine dehydrogenase.  |  Hummel, W., et al. 1988. Anal Biochem. 170: 397-401. PMID: 3394937
  10. Heat Capacities of l-Histidine, l-Phenylalanine, l-Proline, l-Tryptophan and l-Tyrosine.  |  Pokorný, V., et al. 2021. Molecules. 26: PMID: 34299573
  11. Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells.  |  Osuga, Y., et al. 2022. Biochem Biophys Res Commun. 588: 118-124. PMID: 34953208
  12. Synthesis and in vitro/in vivo anticancer evaluation of pentacyclic triterpenoid derivatives linked with l-phenylalanine or l-proline.  |  Yin, Y., et al. 2022. Bioorg Chem. 126: 105865. PMID: 35605555
  13. Amino acids L-phenylalanine and L-lysine involvement in trans and cis piperamides biosynthesis in two Piper species.  |  Cotinguiba, F., et al. 2023. Braz J Biol. 82: e268505. PMID: 36651460

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-Phenylalanine, 100 g

sc-394058
100 g
$112.00

L-Phenylalanine, 500 g

sc-394058A
500 g
$457.00

L-Phenylalanine, 1 kg

sc-394058B
1 kg
$679.00