Molecular structure of L-p-Bromotetramisole oxalate, CAS Number: 62284-79-1
L-p-Bromotetramisole oxalate (CAS 62284-79-1)
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Alternate Names:
L-p-Bromotetramisole oxalate is also known as (−)-p-Bromotetramisole oxalate.
Application:
L-p-Bromotetramisole oxalate is a potent and non-specific alkaline phosphatase inhibitor that strongly activates CFTR chloride channels.
CAS Number:
62284-79-1
Purity:
≥98%
Molecular Weight:
373.22
Molecular Formula:
C11H11BrN2S•C2H2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-p-Bromotetramisole oxalate is an inhibitor of non-specific alkaline phosphatase, comparable in activity to the vanadium compound Orthovanadate (sc-3540). L-p-Bromotetramisole oxalate shows no inhibition of specific phosphatase activity, and the D- enantiomer shows no inhibitory effects against either phosphatase. The activity of tyrosine phosphatases is also reported to be inhibited by L-p-Bromotetramisole oxalate and related compounds. L-p-Bromotetramisole oxalate is also known as 6-Bromolevamisole oxalate, (−)-p-Bromotetramisole oxalate, L-para-Bromotetramisole, and (6S)-6-(4-bromophenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole, monoethanedioate.
L-p-Bromotetramisole oxalate (CAS 62284-79-1) References
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- Levamisole potentiation of fluorouracil antiproliferative activity mimicked by orthovanadate, an inhibitor of tyrosine phosphatase. | Kovach, JS., et al. 1992. J Natl Cancer Inst. 84: 515-9. PMID: 1312177
- The inhibition of alkaline phosphatase by L-p-bromotetramisole. | Borgers, M. and Thoné, F. 1975. Histochemistry. 44: 277-80. PMID: 171243
- Measurement of alkaline phosphatase of intestinal origin in plasma by p-bromotetramisole inhibition. | Kuwana, T. and Rosalki, SB. 1991. J Clin Pathol. 44: 236-7. PMID: 2013625
- Fructose bisphosphatase activity in the serum of rats treated with carbon tetrachloride. | Morata, P., et al. 1989. Biochem Int. 19: 863-9. PMID: 2559730
- Advancement of PI3 Kinase Inhibitor Combination Therapies for PI3K-Aberrant Chordoma. | Heft Neal, ME., et al. 2022. J Neurol Surg B Skull Base. 83: 87-98. PMID: 35155075
- Mechanosensitive Hydrolysis of ATP and ADP in Lamina Propria of the Murine Bladder by Membrane-Bound and Soluble Nucleotidases. | Aresta Branco, MSL., et al. 2022. Front Physiol. 13: 918100. PMID: 35784885
- Further characterization of phosphatase activities using non-specific substrates. | Borgers, M. and Thoné, F. 1976. Histochem J. 8: 301-17. PMID: 59721
- Ultrastructural demonstration of alkaline phosphatase (ALP) and K+-p-nitrophenyl phosphatase (K+-p-NPPase) in the epidermal ionocytes of Blennius sanguinolentus. | Zaccone, G., et al. 1984. Histochemistry. 81: 47-53. PMID: 6088441
- Purification of a specific reversible tyrosine-O-phosphate phosphatase. | Fukami, Y. and Lipmann, F. 1982. Proc Natl Acad Sci U S A. 79: 4275-9. PMID: 6181504
- Phosphotyrosyl-protein phosphatase of TCRC-2 cells. | Swarup, G., et al. 1982. J Biol Chem. 257: 7298-301. PMID: 6282838
- Fructose 1,6-bisphosphatase in the diagnosis of chronic hepatitis. I. Activity measurements of fructose 1,6-bisphosphatase in human serum. | von Rechenberg, H., et al. 1984. Clin Chim Acta. 137: 255-62. PMID: 6321061
- Effect of bromotetramisole on renal phosphate excretion. | Onsgard-Meyer, M., et al. 1996. Proc Soc Exp Biol Med. 213: 193-5. PMID: 8931664
Inhibitor of:
Alkaline Phosphatase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-p-Bromotetramisole oxalate, 5 mg | sc-201431 | 5 mg | $94.00 | |||
L-p-Bromotetramisole oxalate, 50 mg | sc-201431A | 50 mg | $368.00 | |||
L-p-Bromotetramisole oxalate, 100 mg | sc-201431B | 100 mg | $520.00 | |||
L-p-Bromotetramisole oxalate, 1 g | sc-201431C | 1 g | $3641.00 |