Date published: 2026-2-10

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L-NIL dihydrochloride (CAS 159190-45-1)

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Alternate Names:
N6-(1-iminoethyl)-L-lysine, dihydrochloride
Application:
L-NIL dihydrochloride is a selective inhibitor of NOS2 over NOS1
CAS Number:
159190-45-1
Purity:
≥95%
Molecular Weight:
260.16
Molecular Formula:
C8H17N3O22HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-NIL dihydrochloride is recognized in biochemistry research for its inhibitory effects on certain isoforms of the enzyme nitric oxide synthase (NOS), specifically the inducible NOS (iNOS). This specificity allows researchers to dissect the complex roles of nitric oxide (NO) in cellular signaling and immune responses. Studies involving L-NIL dihydrochloride have been instrumental in elucidating the regulation of NO production and its impact on gene expression. Additionally, it is useful in exploring the mechanisms of inflammation where NO plays a pivotal role. The compound is also used in material science to investigate the protective effects of NOS inhibition on various cell types under oxidative stress, providing insights into cellular defense mechanisms.


L-NIL dihydrochloride (CAS 159190-45-1) References

  1. Nitric oxide upregulates induction of PDGF receptor-alpha expression in rat renal mesangial cells and in anti-Thy-1 glomerulonephritis.  |  Beck, KF., et al. 2005. J Am Soc Nephrol. 16: 1948-57. PMID: 15872077
  2. Inhibiting nitric oxide overproduction during hypotensive sepsis increases local oxygen consumption in rat skeletal muscle.  |  Bateman, RM., et al. 2008. Crit Care Med. 36: 225-31. PMID: 18090362
  3. Role of activated macrophages in Acanthamoeba keratitis.  |  Alizadeh, H., et al. 2007. J Parasitol. 93: 1114-20. PMID: 18163346
  4. Chronic inhibition of inducible nitric oxide synthase ameliorates cardiovascular abnormalities in streptozotocin diabetic rats.  |  Nagareddy, PR., et al. 2009. Eur J Pharmacol. 611: 53-9. PMID: 19344709
  5. Proteinuria is reduced by inhibition of inducible nitric oxide synthase in rat renal ischemia-reperfusion injury.  |  Kadkhodaee, M., et al. 2009. Transplant Proc. 41: 2907-9. PMID: 19765470
  6. Inducible nitric oxide synthase increases secretion from inflamed salivary glands.  |  Correia, PN., et al. 2010. Rheumatology (Oxford). 49: 48-56. PMID: 19933597
  7. Activation of RhoA in alcohol-induced intestinal barrier dysfunction.  |  Tong, J., et al. 2013. Inflammation. 36: 750-8. PMID: 23361851
  8. Inducible Nitric Oxide Regulates Na-Glucose Co-transport in a Spontaneous SAMP1/YitFc Mouse Model of Chronic Ileitis.  |  Palaniappan, B., et al. 2020. Nutrients. 12: PMID: 33065982
  9. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.  |  Moore, WM., et al. 1994. J Med Chem. 37: 3886-8. PMID: 7525961
  10. Unaltered vasoconstrictor responsiveness after iNOS inhibition in lungs from chronically hypoxic rats.  |  Resta, TC., et al. 1999. Am J Physiol. 276: L122-30. PMID: 9887064

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-NIL dihydrochloride, 5 mg

sc-205362
5 mg
$48.00

L-NIL dihydrochloride, 10 mg

sc-205362A
10 mg
$82.00