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L-Lysine 7-amido-4-methylcoumarin, acetate salt (CAS 201853-23-8)

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Alternate Names:
H-Lys-AMC⋅AcOH
CAS Number:
201853-23-8
Molecular Weight:
363.41
Molecular Formula:
C16H21N3O3•C2H4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-Lysine 7-amido-4-methylcoumarin, acetate salt is a compound employed in biochemical research, particularly in the study of protease activity. As a fluorogenic substrate, it is used to assay the activity of specific enzymes that cleave the bond between the lysine residue and the amido-4-methylcoumarin moiety, resulting in the release of a fluorescent compound that can be easily quantified. This property makes it valuable in enzyme kinetics and inhibitor screening studies, where changes in fluorescence intensity correlate with enzyme activity. The acetate salt form enhances the solubility of the compound in aqueous solutions, facilitating its use in various experimental conditions. Additionally, L-Lysine 7-amido-4-methylcoumarin is utilized in the characterization of enzyme specificity and in the identification of novel proteases from different biological sources.


L-Lysine 7-amido-4-methylcoumarin, acetate salt (CAS 201853-23-8) References

  1. Purification, cDNA cloning, and expression of a new human blood plasma glutamate carboxypeptidase homologous to N-acetyl-aspartyl-alpha-glutamate carboxypeptidase/prostate-specific membrane antigen.  |  Gingras, R., et al. 1999. J Biol Chem. 274: 11742-50. PMID: 10206990
  2. Identification and characterization of an aromatic amino acid decarboxylase from the filarial nematode, Dirofilaria immitis.  |  Tang, L. and Frank, G. 2001. Biol Chem. 382: 115-22. PMID: 11258661
  3. Substrate recognition properties of oligopeptidase B from Salmonella enterica serovar Typhimurium.  |  Morty, RE., et al. 2002. J Bacteriol. 184: 3329-37. PMID: 12029050
  4. Comparative and functional genomics of the Lactococcus lactis taxon; insights into evolution and niche adaptation.  |  Kelleher, P., et al. 2017. BMC Genomics. 18: 267. PMID: 28356072
  5. A dipeptidylpeptidase secreted by Fasciola hepatica.  |  Carmona, C., et al. 1994. Parasitology. 109 (Pt 1): 113-8. PMID: 8058361

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-Lysine 7-amido-4-methylcoumarin, acetate salt, 100 mg

sc-300887B
100 mg
$185.00

L-Lysine 7-amido-4-methylcoumarin, acetate salt, 250 mg

sc-300887
250 mg
$330.00

L-Lysine 7-amido-4-methylcoumarin, acetate salt, 1 g

sc-300887A
1 g
$1085.00