Molecular structure of L-Leucine 7-amido-4-methylcoumarin hydrochloride, CAS Number: 62480-44-8
L-Leucine 7-amido-4-methylcoumarin hydrochloride (CAS 62480-44-8)
Application:
L-Leucine 7-amido-4-methylcoumarin hydrochloride is Leu-AMC.HCl, a fluorogenic substrate for leucine aminopeptidase
CAS Number:
62480-44-8
Molecular Weight:
324.80
Molecular Formula:
C16H20N2O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
L-Leucine 7-amido-4-methylcoumarin hydrochloride (LAMC-HCl) is a fluorogenic substrate for LAP3 (leucine aminopeptidase). Upon enzyme activity, a bright blue fluorescent dye, 7-amino-4-methylcoumarin, is released. It is used in laboratory experiments to study the function of proteins and enzymes and the effects of drugs on cellular processes. L-Leucine 7-amido-4-methylcoumarin hydrochloride may act to inhibit the activity of enzymes involved in the metabolism of drugs, lipids, and carbohydrates, as well as enzymes employed in the synthesis of proteins. It has also been reported to have an anti-inflammatory effect and reduce the production of pro-inflammatory cytokines.
L-Leucine 7-amido-4-methylcoumarin hydrochloride (CAS 62480-44-8) References
- Periphytic photosynthetic stimulation of extracellular enzyme activity in aquatic microbial communities associated with decaying typha litter. | Francoeur, SN., et al. 2006. Microb Ecol. 52: 662-9. PMID: 17082997
- Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros. | Vaiyapuri, S., et al. 2010. PLoS Negl Trop Dis. 4: e796. PMID: 20706583
- Organic matter recycling in a beach environment influenced by sunscreen products and increased inorganic nutrient supply (Sturla, Ligurian Sea, NW Mediterranean). | Misic, C., et al. 2011. Sci Total Environ. 409: 1689-96. PMID: 21316740
- High-throughput fluorometric measurement of potential soil extracellular enzyme activities. | Bell, CW., et al. 2013. J Vis Exp. e50961. PMID: 24299913
- Silver nanoparticle effects on stream periphyton during short-term exposures. | Gil-Allué, C., et al. 2015. Environ Sci Technol. 49: 1165-72. PMID: 25513720
- Screening the Medicines for Malaria Venture 'Malaria Box' against the Plasmodium falciparum aminopeptidases, M1, M17 and M18. | Paiardini, A., et al. 2015. PLoS One. 10: e0115859. PMID: 25700165
- Bacterial abundance, processes and diversity responses to acidification at a coastal CO2 vent. | Burrell, TJ., et al. 2015. FEMS Microbiol Lett. 362: fnv154. PMID: 26337149
- Temperature Sensitivity as a Microbial Trait Using Parameters from Macromolecular Rate Theory. | Alster, CJ., et al. 2016. Front Microbiol. 7: 1821. PMID: 27909429
- Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases. | Vinh, NB., et al. 2019. J Med Chem. 62: 622-640. PMID: 30537832
- Quantitative proteomic analysis and functional characterization of Acanthamoeba castellanii exosome-like vesicles. | Lin, WC., et al. 2019. Parasit Vectors. 12: 467. PMID: 31597577
- Comparison of protease and aminopeptidase activities in meconium: A pilot study. | Skarżyńska, E., et al. 2020. Biomed Rep. 13: 7. PMID: 32607236
- X-ray crystal structure and specificity of the Toxoplasma gondii ME49 TgAPN2. | Marijanovic, EM., et al. 2020. Biochem J. 477: 3819-3832. PMID: 32926129
- Do plants use root-derived proteases to promote the uptake of soil organic nitrogen? | Greenfield, LM., et al. 2020. Plant Soil. 456: 355-367. PMID: 33087989
- Valorisation of wheat bran to produce natural pigments using selected microorganisms. | Cassarini, M., et al. 2021. J Biotechnol. 339: 81-92. PMID: 34364925
Substrate of:
Fluorogenic, and LAP3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Leucine 7-amido-4-methylcoumarin hydrochloride, 5 mg | sc-218643 | 5 mg | $125.00 | |||
L-Leucine 7-amido-4-methylcoumarin hydrochloride, 25 mg | sc-218643A | 25 mg | $380.00 |