Molecular structure of L-Leucine, CAS Number: 61-90-5
L-Leucine (CAS 61-90-5)
Alternate Names:
Leucine
Application:
L-Leucine is an essential, branched-chain amino acid
CAS Number:
61-90-5
Purity:
≥98%
Molecular Weight:
131.2
Molecular Formula:
C6H13NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-Leucine is an essential, branched-chain amino acid. L-Leucine, an essential amino acid present in most proteins, plays a role in numerous metabolic pathways. It contributes to various biological processes, such as muscle growth, repair, protein synthesis, and energy metabolism. Furthermore, L-Leucine is vital for maintaining nitrogen balance and serves as a precursor for significant metabolic molecules like glucose and fatty acids. It can be obtained from diverse food sources like meat, fish, dairy, legumes, and nuts. L-Leucine′s functionality involves the activation of several enzymes, including branched chain amino acid aminotransferase (BCAT). BCAT aids in converting leucine into its active form called leucyl-tRNA synthetase (LeuRS). LeuRS, in turn, is responsible for activating leucyl-tRNA, an essential component for protein synthesis.
L-Leucine (CAS 61-90-5) References
- L-Leucine and L-isoleucine enhance growth of BBN-induced urothelial tumors in the rat bladder by modulating expression of amino acid transporters and tumorigenesis-associated genes. | Xie, XL., et al. 2013. Food Chem Toxicol. 59: 137-44. PMID: 23747718
- Dietary L-leucine supplementation enhances intestinal development in suckling piglets. | Sun, Y., et al. 2015. Amino Acids. 47: 1517-25. PMID: 25940921
- L-leucine stimulates glutamate dehydrogenase activity and glutamate synthesis by regulating mTORC1/SIRT4 pathway in pig liver. | Wang, T., et al. 2018. Anim Nutr. 4: 329-337. PMID: 30175263
- L-Leucine increases the daily body temperature and affords thermotolerance in broiler chicks. | Han, G., et al. 2019. Asian-Australas J Anim Sci. 32: 842-848. PMID: 30381734
- Improvement of l-Leucine Production in Corynebacterium glutamicum by Altering the Redox Flux. | Wang, YY., et al. 2019. Int J Mol Sci. 20: PMID: 31022947
- Oxidative testicular injury: effect of L-leucine on redox, cholinergic and purinergic dysfunctions, and dysregulated metabolic pathways. | Erukainure, OL., et al. 2021. Amino Acids. 53: 359-380. PMID: 33586041
- Biosynthesis of 3-Hydroxy-3-Methylbutyrate from l-Leucine by Whole-Cell Catalysis. | Gao, R. and Li, Z. 2021. J Agric Food Chem. 69: 3712-3719. PMID: 33734707
- L-leucine promotes axonal outgrowth and regeneration via mTOR activation. | Ma, C., et al. 2021. FASEB J. 35: e21526. PMID: 33813773
- L-leucine stimulation of glucose uptake and utilization involves modulation of glucose - lipid metabolic switch and improved bioenergetic homeostasis in isolated rat psoas muscle ex vivo. | Erukainure, OL., et al. 2021. Amino Acids. 53: 1135-1151. PMID: 34152488
- L-Leucine Improves Metabolic Disorders in Mice With in-utero Cigarette Smoke Exposure. | Zeng, Y., et al. 2021. Front Physiol. 12: 700246. PMID: 34276421
- L-Leucine Promotes STAT1 and ISGs Expression in TGEV-Infected IPEC-J2 Cells via mTOR Activation. | Du, J., et al. 2021. Front Immunol. 12: 656573. PMID: 34367129
- L-Leucine In Ovo Administration Causes Growth Retardation and Modifies Specific Amino Acid Metabolism in Broiler Embryos. | Han, G., et al. 2021. J Poult Sci. 58: 163-170. PMID: 34447280
- Transcriptome analysis of L-leucine-producing Corynebacterium glutamicum under the addition of trimethylglycine. | Wang, J., et al. 2022. Amino Acids. 54: 229-240. PMID: 34837555
- Improvement of acetyl-CoA supply and glucose utilization increases l-leucine production in Corynebacterium glutamicum. | Wang, Y., et al. 2022. Biotechnol J. 17: e2100349. PMID: 34870372
- L-leucine supplementation reduces growth performance accompanied by changed profiles of plasma amino acids and expression of jejunal amino acid transporters in breast-fed intra-uterine growth-retarded piglets. | Ji, Y., et al. 2022. Br J Nutr. 1-33. PMID: 36047051
Inhibitor of:
BCKDE1A, BCKDHB, CAT-3, ERAP2, Gcn4, GPx-8, NEPH2, ProRS, SLC43A2, SLC7A6, SLC7A9, and TFR2.Activator of:
α-actinin-3, β1-Adaptin, 1700008B15Rik, 2400001E08Rik, 3-Hydroxybutyrate Dehydrogenase, 4E-BP2, 4E-BP3, 5430416O09Rik, AARSD1, ACAT-1, ACSM5, ADSL, AdSS1, Akp-3, Aminoacylase-1, Aminopeptidase P1, apoOL, ArgRS, ATP11, BAT2, BC024814, BCKDE1A, Bet1, C20orf135, C3orf60, cathepsin Q, CHCHD3, CHCHD6, cHMGCS, collectrin, COQ9, CPS2, CysRS, DBT, DEPDC5, DEPDC6, Dpb11, EF-1 α2, EG432502, EG435337, eIF1, eIF4E, eIF4GII, eIF5A1, ERAL1, ERAP2, eRF3a, FARSLB, FASTKD2, Gap1, GATSL1, GATSL2, GGL, Gln3, GLUD1, GLULD1, GluRS, Glutamate Dehydrogenase, Gm853, GPAM, GPR142, GPR146, GPR41, GPT2, GRSF-1, GS1, HAL, HCCS, HCG3, Hep C NS4a, HIBCH, HLCS, HMGCL, HXK III, IARS2, IGF2BP2, IVD, JAK2, KGA_Gls, KIAA1609, LAAO, LAMTOR4, LAT2, LeuRS, LGA, LPAAT-θ, LYRM4, LYRM9, MCCA, MetRS, Mitochondrial Inner Membrane, Mitochondrial Topo I, MLSN1, MMD2, MPV17, MRM1, MRP-L14, MRP-L15, MRP-L17, MRP-L19, MRP-L2, MRP-L27, MRP-L4, MRP-L45, MRP-L49, MRP-L52, MRP-L54, MRP-L55, MRP-L9, MRP-S12, MRP-S21, MRP-S5, MRP-S6, MRRF, MTO1, MTP18, MYH13, Myozenin 2, NARS2, ND5, NDUFAF1, NDUFAF7, NDUFB5, NSUN3, NSUN5, P5CR2, p70 S6 kinase β, PARS2, PAT2, Pepsin A, PEPT2, PET100, PIPOX, PM20D1, PPAN, PQLC2, PRAS40, PROT, QRSL1, Rag A (RRAGA), Rag B, Raptor, RARS2, REDD-2, Rheb, Ribosomal Protein L11, Ribosomal Protein L23a, Ribosomal Protein L27, Ribosomal Protein S14, Ribosomal Protein S19, Ribosomal Protein S25, Ribosomal Protein S6, Ribosomal ProteinL18, RPL7A, RPUSD2, RSL1D1, SAMC, SH-PTP1, Shh, SLC22A12, SLC25A22, SLC25A40, SLC38A6, SLC38A8, SLC6A14, SLC6A15, SLC6A19, SLC7A10, SLC7A9, SNAT1, SNAT2, SNAT5, SNAT6, SZT2, TAMM41, Tap42, TARSL1, Titin, Tor1, TORC1, UBXD7, USP30, ValRS, VARS2, VPS41, WARS2, WDR92, XRCC6BP1, Y+LAT1, and YLAT1.Substrate of:
IRAP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Leucine, 25 g | sc-364173 | 25 g | $21.00 | |||
L-Leucine, 100 g | sc-364173A | 100 g | $61.00 |