Date published: 2026-5-10

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L-Leucine-5,5,5-d3 (CAS 87828-86-2)

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Alternate Names:
(2S)-2-Amino-4-methylpentanoic Acid-d3; (S)-(+)-Leucine-d3
CAS Number:
87828-86-2
Molecular Weight:
134.19
Molecular Formula:
C6H10D3NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-Leucine, particularly the labeled form L-Leu-5,5,5-d3, is utilized as a tracer in the investigation of human apolipoprotein B metabolism. As an essential amino acid, L-Leucine serves as a nutrient signal that stimulates protein synthesis. Furthermore, it activates the mammalian target of rapamycin kinase, a regulator of cell growth. L-Leu-5,5,5-d3 demonstrates various biochemical and physiological effects. It has been observed to enhance protein synthesis rate and improve the efficiency of protein synthesis in cells.


L-Leucine-5,5,5-d3 (CAS 87828-86-2) References

  1. Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors.  |  Foster, LJ., et al. 2003. Proc Natl Acad Sci U S A. 100: 5813-8. PMID: 12724530
  2. Downregulated expression of HSP27 in human low-grade glioma tissues discovered by a quantitative proteomic analysis.  |  Shen, G., et al. 2010. Proteome Sci. 8: 17. PMID: 20346134
  3. Acid stress-mediated metabolic shift in Lactobacillus sanfranciscensis LSCE1.  |  Serrazanetti, DI., et al. 2011. Appl Environ Microbiol. 77: 2656-66. PMID: 21335381
  4. The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.  |  Lei, Y., et al. 2012. Immunity. 36: 933-46. PMID: 22749352
  5. Proteome-wide measurement of non-canonical bacterial mistranslation by quantitative mass spectrometry of protein modifications.  |  Cvetesic, N., et al. 2016. Sci Rep. 6: 28631. PMID: 27377007
  6. Characterization of Arginine Catabolism by Lactic Acid Bacteria Isolated from Kimchi.  |  Hwang, H. and Lee, JH. 2018. Molecules. 23: PMID: 30469432
  7. Ammonium Fluoride as Suitable Additive for HILIC-Based LC-HRMS Metabolomics.  |  Narduzzi, L., et al. 2019. Metabolites. 9: PMID: 31783638
  8. Effects of MYBPC3 loss-of-function mutations preceding hypertrophic cardiomyopathy.  |  Helms, AS., et al. 2020. JCI Insight. 5: PMID: 31877118
  9. Evaluation of a Common Internal Standard Material to Reduce Inter-Laboratory Variation and Ensure the Quality, Safety and Efficacy of Expanded Newborn Screening Results When Using Flow Injection Analysis Tandem Mass Spectrometry with Internal Calibration.  |  Carling, RS., et al. 2020. Int J Neonatal Screen. 6: PMID: 33228114
  10. Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice.  |  Wu, W., et al. 2021. Theranostics. 11: 8993-9008. PMID: 34522223
  11. The discovery of combined toxicity effects and mechanisms of hexaconazole and arsenic to mice based on untargeted metabolomics.  |  Sun, D., et al. 2021. Ecotoxicol Environ Saf. 226: 112859. PMID: 34624535
  12. Integrated Metagenomics and Metabolomics to Reveal the Effects of Policosanol on Modulating the Gut Microbiota and Lipid Metabolism in Hyperlipidemic C57BL/6 Mice.  |  Zhai, Z., et al. 2021. Front Endocrinol (Lausanne). 12: 722055. PMID: 34707567
  13. Short- and long-read metagenomics expand individualized structural variations in gut microbiomes.  |  Chen, L., et al. 2022. Nat Commun. 13: 3175. PMID: 35676264

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-Leucine-5,5,5-d3, 1 g

sc-460670
1 g
$500.00