Molecular structure of L-Hyoscyamine, CAS Number: 101-31-5
L-Hyoscyamine (CAS 101-31-5)
Alternate Names:
Daturine; (−)-Hyoscyamine
Application:
L-Hyoscyamine is a non-selective, competitive antagonist of the muscarinic acetylcholine receptors
CAS Number:
101-31-5
Purity:
≥98%
Molecular Weight:
289.38
Molecular Formula:
C17H23NO3
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-Hyoscyamine is a non-selective, competitive antagonist of the muscarinic acetylcholine receptor, specifically M1, M2, M3, M4, and M5.L-Hyoscyamine, a tropane alkaloid sourced from Solanaceae family plants like henbane, nightshade, and jimsonweed, stands as a natural compound. Explorations into its impact on the central nervous system, gastrointestinal tract, and cardiovascular system have been pursued. The application of L-Hyoscyamine spans in vivo and in vitro studies. Conversely, in vitro analyses occur within controlled laboratory environments, employing cells or tissues.
L-Hyoscyamine (CAS 101-31-5) References
- Determination of L-hyoscyamine in atropine and D-hyoscyamine in L-hyoscyamine by chiral capillary electrophoresis as an alternative to polarimetry. | Heine, S., et al. 2003. Electrophoresis. 24: 2687-92. PMID: 12900883
- Atropine as an antisialogogue, compared with l-hyoscyamine (bellafoline), scopolamine butylbromide (buscopan) and oxyphenonium (antrenyl). | DIAMANT, H. and FEINMESSER, M. 1959. Br J Anaesth. 31: 205-9. PMID: 13662482
- Anticholinergic activity of 107 medications commonly used by older adults. | Chew, ML., et al. 2008. J Am Geriatr Soc. 56: 1333-41. PMID: 18510583
- Natural compounds endowed with cholinergic or anticholinergic activity. Enhancement of acetylcholine release by a quaternary derivative of L-hyoscyamine. | Souccar, C., et al. 2010. J Mol Neurosci. 40: 138-42. PMID: 19688610
- Densitometric TLC analysis for the control of tropane and steroidal alkaloids in Lycium barbarum. | Kokotkiewicz, A., et al. 2017. Food Chem. 221: 535-540. PMID: 27979237
- A method using L-hyoscyamine for the study of muscarinic acetylcholine receptor binding in vivo. | Palmér, L., et al. 1987. Pharmacol Toxicol. 60: 54-7. PMID: 3562391
- Purification and characterization of hyoscyamine 6 beta-hydroxylase from root cultures of Hyoscyamus niger L. Hydroxylase and epoxidase activities in the enzyme preparation. | Hashimoto, T. and Yamada, Y. 1987. Eur J Biochem. 164: 277-85. PMID: 3569262
- A validated liquid chromatography-tandem mass spectrometry method for the determination of l-hyoscyamine in human plasma: Application in a clinical study. | Duan, Y., et al. 2022. Biomed Chromatogr. 36: e5485. PMID: 35996811
- MIL-53(Fe)-derived ant nest structured porous carbon nanospheres CuFeS2 /C for the determination of atropine enantiomeric impurity L-hyoscyamine. | Zhu, J. and Li, K. 2022. Chirality. 34: 1526-1537. PMID: 36190759
- Mastocytosis treated with l-hyoscyamine (Egazil). | Berg, B., et al. 1968. Acta Med Scand. 184: 383-7. PMID: 5732552
- Radioimmunoassay for atropine and l-hyoscyamine. | Virtanen, R., et al. 1980. Acta Pharmacol Toxicol (Copenh). 47: 208-12. PMID: 7446137
- Prejunctional effect of quaternary derivatives of l-hyoscyamine at the rat neuromuscular junction. A structure-activity relationship study. | Souccar, C., et al. 1994. Gen Pharmacol. 25: 1397-404. PMID: 7896051
- Development and validation of an LC/MS/MS method for the determination of L-hyoscyamine in human plasma. | Xu, A., et al. 1995. J Pharm Biomed Anal. 14: 33-42. PMID: 8833964
Inhibitor of:
AChR, mAChR M3, and motilin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Hyoscyamine, 1 g | sc-295290 | 1 g | $222.00 | |||
L-Hyoscyamine, 5 g | sc-295290A | 5 g | $408.00 |