Date published: 2025-12-15

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L-homopropargylglycine (CAS 98891-36-2)

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Alternate Names:
(S)-2-aminohex-5-ynoic acid; H-Hpg-OH
Application:
L-homopropargylglycine is a reactive methionine analog
CAS Number:
98891-36-2
Purity:
≥97%
Molecular Weight:
127.14
Molecular Formula:
C6H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-homopropargylglycine is a reactive analog of methionine that contains an alkyne moiety. When introduced, this compound can replace methionine in newly synthesized proteins. The labeled proteins can then be captured through click chemistry, making it a fast, sensitive, and non-radioactive alternative to [35S]-methionine for detecting nascent protein synthesis.


L-homopropargylglycine (CAS 98891-36-2) References

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  2. Conjugation of proteins by installing BIO-orthogonally reactive groups at their N-termini.  |  Soundrarajan, N., et al. 2012. PLoS One. 7: e46741. PMID: 23056430
  3. Transient translational quiescence in primordial germ cells.  |  Oulhen, N., et al. 2017. Development. 144: 1201-1210. PMID: 28235822
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  7. The ubiquitination-deubiquitination cycle on the ribosomal protein eS7A is crucial for efficient translation.  |  Takehara, Y., et al. 2021. iScience. 24: 102145. PMID: 33665564
  8. Amino Acid Analog Induces Stress Response in Marine Synechococcus.  |  Michels, DE., et al. 2021. Appl Environ Microbiol. 87: e0020021. PMID: 33990310
  9. Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes.  |  Shen, Y., et al. 2021. STAR Protoc. 2: 100616. PMID: 34189479
  10. The development of shape. Modular control of growth in the lepidopteran forewing.  |  McKenna, KZ. and Nijhout, HF. 2022. J Exp Zool B Mol Dev Evol. 338: 170-180. PMID: 34710273
  11. Mito-FUNCAT-FACS reveals cellular heterogeneity in mitochondrial translation.  |  Kimura, Y., et al. 2022. RNA. 28: 895-904. PMID: 35256452
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  13. Differential toxicity of bioorthogonal non-canonical amino acids (BONCAT) in Escherichia coli.  |  Landor, LAI., et al. 2023. J Microbiol Methods. 206: 106679. PMID: 36720393
  14. High-throughput Assessment of Mitochondrial Protein Synthesis in Mammalian Cells Using Mito-FUNCAT FACS.  |  Saito, H., et al. 2023. Bio Protoc. 13: PMID: 36816992
  15. Metabolic labeling and LC-MS/MS-based identification of interleukin-1α-induced secreted proteomes from epithelial cells in the presence or absence of serum.  |  Priester, J., et al. 2023. STAR Protoc. 4: 102195. PMID: 37004159

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-homopropargylglycine, 100 mg

sc-363439A
100 mg
$596.00

L-homopropargylglycine, 200 mg

sc-363439
200 mg
$653.00

L-homopropargylglycine, 1 g

sc-363439B
1 g
$1760.00