Molecular structure of L-Homocysteine, CAS Number: 6027-13-0
L-Homocysteine (CAS 6027-13-0)
See product citations (3)
Alternate Names:
(S)-2-Amino-4-mercaptobutyric acid
Application:
L-Homocysteine is a useful reference standard for measuring L-Homocysteine levels
CAS Number:
6027-13-0
Purity:
≥95%
Molecular Weight:
135.18
Molecular Formula:
C4H9NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-Homocysteine is an indispensable amino acid that plays a vital role in protein, fat, and carbohydrate metabolism. Additionally, it contributes to the synthesis of various vitamins and hormones. L-homocysteine, derived from methionine, is a sulfur-containing amino acid naturally present in the human body at physiological levels. Elevated levels of L-Homocysteine have been linked to coronary heart diseases, suggesting its potential involvement in their development. L-Homocysteine can react with nitric oxide to generate an anion radical, effectively scavenging free radicals like peroxynitrite and reducing oxidative damage. Moreover, it inhibits collagen synthesis and lysyl oxidase activity. L-homocysteine has demonstrated its ability to scavenge hydroxyl radicals, which are instrumental in lipid peroxidation processes, thereby exhibiting antioxidant effects on LDL oxidation.
L-Homocysteine (CAS 6027-13-0) References
- Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease. | Poddar, R., et al. 2001. Circulation. 103: 2717-23. PMID: 11390343
- Yeast cystathionine beta-synthase reacts with L-allothreonine, a non-natural substrate, and L-homocysteine to form a new amino acid, 3-methyl-L-cystathionine. | Jhee, KH., et al. 2002. Biochemistry. 41: 1828-35. PMID: 11827527
- L-Homocysteine and L-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells. | Heydrick, SJ., et al. 2004. Free Radic Biol Med. 36: 632-40. PMID: 14980706
- Targeting of metallothionein by L-homocysteine: a novel mechanism for disruption of zinc and redox homeostasis. | Barbato, JC., et al. 2007. Arterioscler Thromb Vasc Biol. 27: 49-54. PMID: 17082481
- Homocysteine measurement by Vitros Microtip homocysteine assay. | Martens, GA., et al. 2008. Clin Chem Lab Med. 46: 283-6. PMID: 18324911
- Highly enhanced electrochemiluminescent strategy for tumor biomarkers detection with in situ generation of L-homocysteine for signal amplification. | Wang, H., et al. 2014. Anal Chim Acta. 815: 16-21. PMID: 24560368
- L-Cysteine/D,L-homocysteine-regulated ileum motility via system L and B°(,+) transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments. | Yamane, S., et al. 2015. Eur J Pharmacol. 764: 471-479. PMID: 26201052
- Homocysteine Exposure Impairs Myocardial Resistance to Ischaemia Reperfusion and Oxidative Stress. | Almashhadany, A., et al. 2015. Cell Physiol Biochem. 37: 2265-74. PMID: 26624798
- Central cardiovascular actions of L-homocysteine microinjected into ventrolateral medullary autonomic areas of the rat. | Takemoto, Y. 2016. Amino Acids. 48: 2215-25. PMID: 27178024
- l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia. | Leng, YP., et al. 2018. Br J Pharmacol. 175: 1157-1172. PMID: 28631302
- Probucol reverses homocysteine induced inflammatory monocytes differentiation and oxidative stress. | Zhang, M., et al. 2018. Eur J Pharmacol. 818: 67-73. PMID: 29055785
- A comparison of L-carnitine and several cardiovascular-related biomarkers between healthy vegetarians and omnivores. | Lin, TJ., et al. 2019. Nutrition. 66: 29-37. PMID: 31202134
- Novel method for l-methionine determination using l-methionine decarboxylase and application of the enzyme for l-homocysteine determination. | Okawa, A., et al. 2020. Biosci Biotechnol Biochem. 84: 927-935. PMID: 31959065
- Selection of DNA Aptamers for Root Exudate l-Serine Using Multiple Selection Strategies. | Mastronardi, E., et al. 2021. J Agric Food Chem. 69: 4294-4306. PMID: 33600189
- Characterization and application of l-methionine γ-lyase Q349S mutant enzyme with an enhanced activity toward l-homocysteine. | Okawa, A., et al. 2022. J Biosci Bioeng. 133: 213-221. PMID: 34953671
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Homocysteine, 50 mg | sc-280883 | 50 mg | $287.00 | |||
L-Homocysteine, 100 mg | sc-280883A | 100 mg | $520.00 |