Date published: 2026-4-29

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L-Gulono-1,4-lactone (CAS 1128-23-0)

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Alternate Names:
L-Gulonolactone; L-Gulonic-gamma-lactone
Application:
L-Gulono-1,4-lactone is a precursor of ascorbic acid
CAS Number:
1128-23-0
Molecular Weight:
178.14
Molecular Formula:
C6H10O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-Gulono-1,4-lactone serves as a precursor for ascorbic acid synthesis through the enzymatic action of gulonolactone oxidase. This compound has been extensively utilized in researching the impact of vitamin C on human health and diseases, shedding light on its pivotal role in vitamin C biosynthesis. Furthermore, L-Gulono-1,4-lactone has proven valuable in the realm of drug metabolism studies.


L-Gulono-1,4-lactone (CAS 1128-23-0) References

  1. L-Ascorbate Biosynthesis Involves Carbon Skeleton Rearrangement in the Nematode Caenorhabditis elegans.  |  Yabuta, Y., et al. 2020. Metabolites. 10: PMID: 32824560
  2. Growth and Antioxidant-Related Effects of the Reestablished Ascorbic Acid Pathway in Zebrafish (Danio rerio) by Genomic Integration of L-Gulonolactone Oxidase From Cloudy Catshark (Scyliorhinus torazame).  |  Shanaka, KASN., et al. 2021. Front Physiol. 12: 685595. PMID: 34290620
  3. Metabolism and Regulation of Ascorbic Acid in Fruits.  |  Zheng, X., et al. 2022. Plants (Basel). 11: PMID: 35736753
  4. Metabolomic profiling identifies biomarkers and metabolic impacts of surgery for colorectal cancer.  |  Zhuang, F., et al. 2022. Front Surg. 9: 913967. PMID: 36090329
  5. Advances in Novel Animal Vitamin C Biosynthesis Pathways and the Role of Prokaryote-Based Inferences to Understand Their Origin.  |  Duque, P., et al. 2022. Genes (Basel). 13: PMID: 36292802
  6. Effect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut microbiota.  |  Han, Q., et al. 2023. CNS Neurosci Ther. 29: 633-645. PMID: 36468415
  7. Ascorbate synthesis as an alternative electron source for mitochondrial respiration: Possible implications for the plant performance.  |  Matos, IF., et al. 2022. Front Plant Sci. 13: 987077. PMID: 36507441
  8. Physiological and metabolomic analysis reveals maturity stage-dependent nitrogen regulation of vitamin C content in pepper fruit.  |  Zhang, L., et al. 2022. Front Plant Sci. 13: 1049785. PMID: 36714702
  9. Effects of altitude on the gut microbiome and metabolomics of Sanhe heifers.  |  Zhang, X., et al. 2023. Front Microbiol. 14: 1076011. PMID: 36910192
  10. The Role of Vitamin C and Vitamin D in the Pathogenesis and Therapy of Periodontitis-Narrative Review.  |  Ustianowski, Ł., et al. 2023. Int J Mol Sci. 24: PMID: 37047746
  11. The Biochemistry and Effectiveness of Antioxidants in Food, Fruits, and Marine Algae.  |  Pruteanu, LL., et al. 2023. Antioxidants (Basel). 12: PMID: 37107235
  12. Identification of the GDP-L-Galactose Phosphorylase Gene as a Candidate for the Regulation of Ascorbic Acid Content in Fruits of Capsicum annuum L.  |  Wang, Y., et al. 2023. Int J Mol Sci. 24: PMID: 37108695
  13. Genome-Wide Identification and Comparative Transcriptome Methods Reveal FaMDHAR50 Regulating Ascorbic Acid Regeneration and Quality Formation of Strawberry Fruits.  |  Hou, G., et al. 2023. Int J Mol Sci. 24: PMID: 37298465

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-Gulono-1,4-lactone, 5 g

sc-221805
5 g
$93.00