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L-Dihydroorotic acid (CAS 5988-19-2)

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Alternate Names:
2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid; L-Hydroorotic acid; Dihydro-L-orotic acid
Application:
L-Dihydroorotic acid is a metabolite
CAS Number:
5988-19-2
Purity:
≥98%
Molecular Weight:
158.11
Molecular Formula:
C5H6N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-Dihydroorotic acid is a compound that plays a significant role in biochemical research, particularly in the study of pyrimidine biosynthesis. It is an intermediate in the de novo synthesis of pyrimidines, which are essential components of nucleic acids. Researchers utilize L-Dihydroorotic acid to investigate the enzyme dihydroorotate dehydrogenase, which catalyzes the oxidation of dihydroorotic acid to orotic acid in the pyrimidine biosynthetic pathway. This research provides insights into the regulation and control of nucleotide synthesis within cells. Additionally, L-Dihydroorotic acid is used in enzymology studies to explore the binding affinity and reaction kinetics of substrates and inhibitors related to the metabolic pathway. The compound′s role in fundamental cellular processes makes it useful for understanding genetic regulation and the effects of mutations on metabolism.


L-Dihydroorotic acid (CAS 5988-19-2) References

  1. Determination of orotic and dihydroorotic acids in biological fluids and tissues.  |  Kesner, L., et al. 1975. Clin Chem. 21: 353-5. PMID: 1112044
  2. Coordination of the synthesis of the enzymes in the pyrimidine pathway of E. coli.  |  BECKWITH, JR., et al. 1962. J Mol Biol. 5: 618-34. PMID: 13970180
  3. DIASTEREOISOMERS OF BETA-HYDROXYASPARTIC ACID AS ASPARTIC ACID ANTAGONISTS IN BACTERIA.  |  ZYGMUNT, WA., et al. 1963. Arch Biochem Biophys. 102: 270-5. PMID: 14061731
  4. In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.  |  Peters, GJ., et al. 1990. Cancer Res. 50: 4644-9. PMID: 2164443
  5. The relation between inhibition of cell growth and of dihydroorotic acid dehydrogenase by brequinar sodium.  |  de Kant, E., et al. 1989. Cancer Lett. 46: 123-7. PMID: 2546667
  6. Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390).  |  Peters, GJ., et al. 1987. Invest New Drugs. 5: 235-44. PMID: 2822596
  7. Metabolomics research on potential role for 9-cis-retinoic acid in breast cancer progression.  |  Wu, J., et al. 2018. Cancer Sci. 109: 2315-2326. PMID: 29737597
  8. Bovine liver dihydropyrimidine amidohydrolase: pH dependencies of inactivation by chelators and steady-state kinetic properties.  |  Lee, MH., et al. 1986. Arch Biochem Biophys. 248: 368-78. PMID: 3089167
  9. Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study.  |  Zhang, H., et al. 2020. J Diabetes Res. 2020: 3049098. PMID: 32190695
  10. Deoiled sunflower seeds ameliorate depression by promoting the production of monoamine neurotransmitters and inhibiting oxidative stress.  |  Lu, X., et al. 2021. Food Funct. 12: 573-586. PMID: 33367360
  11. A facile tritium release assay for mammalian L-dihydroorotate dehydrogenase.  |  Kensler, TW., et al. 1981. Anal Biochem. 117: 315-9. PMID: 6275738
  12. Purification and properties of dihydroorotate oxidase from Crithidia fasciculata and Trypanosoma brucei.  |  Pascal, RA., et al. 1983. Biochemistry. 22: 171-8. PMID: 6299333
  13. A straightforward method for the simultaneous preparation of radiolabeled L-dihydroörotic and N-carbamyl-L-aspartic acids.  |  Kensler, TW., et al. 1981. Anal Biochem. 111: 49-53. PMID: 7235240
  14. Targeting DHODH with AG-636 Induces Apoptosis and Differentiation and Inhibits Mitochondrial Function in AML, Translating into Anti-Tumor Efficacy in Vitro and in Vivo  |  Zhihong Zeng * 1, Natalia Baran PhDMD 1, Sergej Konoplev * 2, Antonio Cavazos * 3, Qi Zhang * 1, Vinitha Mary Kuruvilla MSc * 1, Philip Lorenzi 4, Hagop M. Kantarjian MD 1, Michael Andreeff MD PhD 5, Courtney D. DiNardo MDMSc 6, Joshua Murtie * 7, Danielle Ulanet * 7, Marina Y Konopleva MD PhD 8. 2019. Blood. 134: 3911.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-Dihydroorotic acid, 1 g

sc-207798
1 g
$177.00

L-Dihydroorotic acid, 5 g

sc-207798A
5 g
$628.00