Date published: 2025-9-23

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L-Cystine (CAS 56-89-3)

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Alternate Names:
[R-(R*,R*)]-3,3′-dithiobis[2-aminopropanoic acid]; Cystine; Dicysteine; Gelucystine
Application:
L-Cystine is a non-essential amino acid vital for human development
CAS Number:
56-89-3
Purity:
≥98%
Molecular Weight:
240.30
Molecular Formula:
C6H12N2O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-Cystine is an amino acid that plays a significant role in protein science and structural biology research. It is particularly noted for its ability to form disulfide bonds, which are for the stabilization of tertiary and quaternary protein structures. In the laboratory, L-cystine is studied for its contributions to the folding and stability of proteins, and these insights are valuable in understanding the mechanisms of protein misfolding and aggregation. Additionally, L-cystine is used in studies that focus on redox biology, given its involvement in cellular redox homeostasis and signaling pathways through its interconversion with the reduced form, L-cysteine. It is also a subject of interest in the field of materials science, where L-cystine-based materials are explored for their potential applications in biotechnology and nanotechnology, such as the development of biocompatible polymers and chemical delivery systems.


L-Cystine (CAS 56-89-3) References

  1. L-lactate inhibits L-cystine/L-glutamate exchange transport and decreases glutathione content in rat cultured astrocytes.  |  Koyama, Y., et al. 2000. J Neurosci Res. 59: 685-91. PMID: 10686597
  2. Utilization of L-cystine as a source of carbon and nitrogen by various fungi.  |  Kunert, J. 1989. Acta Univ Palacki Olomuc Fac Med. 123: 351-64. PMID: 2533843
  3. L-Cysteine metabolism and its nutritional implications.  |  Yin, J., et al. 2016. Mol Nutr Food Res. 60: 134-46. PMID: 25929483
  4. l-Cystine Diamides as l-Cystine Crystallization Inhibitors for Cystinuria.  |  Hu, L., et al. 2016. J Med Chem. 59: 7293-8. PMID: 27409142
  5. Role of Molecular Recognition in l-Cystine Crystal Growth Inhibition.  |  Poloni, LN., et al. 2017. Cryst Growth Des. 17: 2767-2781. PMID: 29234242
  6. Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria.  |  Yang, Y., et al. 2018. Bioorg Med Chem Lett. 28: 1303-1308. PMID: 29571572
  7. l-Cystine-Crosslinked Polypeptide Nanogel as a Reduction-Responsive Excipient for Prostate Cancer Chemotherapy.  |  He, L., et al. 2016. Polymers (Basel). 8: PMID: 30979130
  8. L-Cystine-Containing Hair-Growth Formulation Supports Protection, Viability, and Proliferation of Keratinocytes.  |  Riegel, K., et al. 2020. Clin Cosmet Investig Dermatol. 13: 499-510. PMID: 32801826
  9. Safety and efficacy of l-cystine produced using Pantoea ananatis strain NITE BP-02525 for all animal species.  |  , ., et al. 2020. EFSA J. 18: e06020. PMID: 32874229
  10. l-Cystine is associated with the dysconnectivity of the default-mode network and salience network in attention-deficit/hyperactivity disorder.  |  Wang, LJ., et al. 2021. Psychoneuroendocrinology. 125: 105105. PMID: 33338922
  11. Extracellular Concentration of L-Cystine Determines the Sensitivity to System xc - Inhibitors.  |  Abdullah, M. and Lee, SJ. 2022. Biomol Ther (Seoul). 30: 184-190. PMID: 34667132
  12. Crystalline structures of L-cysteine and L-cystine: a combined theoretical and experimental characterization.  |  Su, Y., et al. 2022. Amino Acids. 54: 1123-1133. PMID: 35296914
  13. Plasma-assisted in-situ preparation of L-cystine functionalized silver nanoparticle: An intelligent multicolor nano-sensing of cadmium and paracetamol from environmental sample.  |  Okla, MK., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 279: 121330. PMID: 35605418

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-Cystine, 25 g

sc-394415
25 g
$48.00

L-Cystine, 250 g

sc-394415A
250 g
$76.00

L-Cystine, 1 kg

sc-394415B
1 kg
$189.00

L-Cystine, 5 kg

sc-394415C
5 kg
$814.00

L-Cystine, 10 kg

sc-394415D
10 kg
$1572.00