Molecular structure of L-Cysteine-glutathione disulfide, CAS Number: 13081-14-6
L-Cysteine-glutathione disulfide (CAS 13081-14-6)
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Alternate Names:
CYSH-GSH
Application:
L-Cysteine-glutathione disulfide is a ubiquitous substance in mammalian cells
CAS Number:
13081-14-6
Purity:
≥98%
Molecular Weight:
426.47
Molecular Formula:
C13H22N4O8S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-Cysteine-glutathione Disulfide (L-CySSG) is a ubiquitous glutathione (GSH) derivative present in mammalian cells. This compound is the oxidized form of free GSH and L-Cysteine, comprised of the GSH tripeptide linked via a disulfide bond to L-Cysteine. L-Cysteine-glutathione Disulfide may act to protect mice against acetaminophen-induced hepatotoxicity, however the D-cysteine adduct was shown to be totally ineffective in this regard.
L-Cysteine-glutathione disulfide (CAS 13081-14-6) References
- The spawning pheromone cysteine-glutathione disulfide ('nereithione') arouses a multicomponent nuptial behavior and electrophysiological activity in Nereis succinea males. | Ram, JL., et al. 1999. FASEB J. 13: 945-52. PMID: 10224237
- Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione. | Berkeley, LI., et al. 2003. J Biochem Mol Toxicol. 17: 95-7. PMID: 12717742
- Computational and mutational analysis of human glutaredoxin (thioltransferase): probing the molecular basis of the low pKa of cysteine 22 and its role in catalysis. | Jao, SC., et al. 2006. Biochemistry. 45: 4785-96. PMID: 16605247
- Comparative efficacies of 2 cysteine prodrugs and a glutathione delivery agent in a colitis model. | Oz, HS., et al. 2007. Transl Res. 150: 122-9. PMID: 17656332
- Two novel monothiol glutaredoxins from Saccharomyces cerevisiae provide further insight into iron-sulfur cluster binding, oligomerization, and enzymatic activity of glutaredoxins. | Mesecke, N., et al. 2008. Biochemistry. 47: 1452-63. PMID: 18171082
- The Incomplete Glutathione Puzzle: Just Guessing at Numbers and Figures? | Deponte, M. 2017. Antioxid Redox Signal. 27: 1130-1161. PMID: 28540740
- Systematic re-evaluation of the bis(2-hydroxyethyl)disulfide (HEDS) assay reveals an alternative mechanism and activity of glutaredoxins. | Begas, P., et al. 2015. Chem Sci. 6: 3788-3796. PMID: 29218148
- Enzymatic glutaredoxin-dependent method to determine glutathione and protein S-glutathionylation using fluorescent eosin-glutathione. | Coppo, L., et al. 2019. Anal Biochem. 568: 24-30. PMID: 30597126
- l-Histidine, arachidonic acid, biliverdin, and l-cysteine-glutathione disulfide as potential biomarkers for cured pulmonary tuberculosis. | Yi, WJ., et al. 2019. Biomed Pharmacother. 116: 108980. PMID: 31125821
- Stability of glutathione added as a supplement to parenteral nutrition. | Raichani, NE., et al. 2022. JPEN J Parenter Enteral Nutr. 46: 1080-1087. PMID: 34669977
- Extracellular Calcium Receptor as a Target for Glutathione and Its Derivatives. | Goralski, T. and Ram, JL. 2022. Int J Mol Sci. 23: PMID: 35054903
- Biosynthesis of S-(2-hydroxy-2-carboxyethylthio)-L-cysteine (3-mercaptolactate-cysteine disulfide) by the rat heart. | Ubuka, T., et al. 1983. Biochem Int. 6: 291-6. PMID: 6679325
- Metabolism of 3-mercaptopyruvate in rat tissues. | Kiguchi, S. 1983. Acta Med Okayama. 37: 85-91. PMID: 6869067
- Prevention of acetaminophen- and naphthalene-induced cataract and glutathione loss by CySSME. | Rathbun, WB., et al. 1996. Invest Ophthalmol Vis Sci. 37: 923-9. PMID: 8603877
- An HPLC radiotracer method for assessing the ability of L-cysteine prodrugs to maintain glutathione levels in the cultured rat lens. | Holleschau, AM., et al. 1996. Curr Eye Res. 15: 501-10. PMID: 8724799
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Cysteine-glutathione disulfide, 10 mg | sc-211701 | 10 mg | $416.00 |