L-CCG-IV CAS: 117857-95-1
MF: C6H9NO4
MW: 159.14
A potent small molecule agonist at the NMDA receptor.

L-CCG-IV (CAS 117857-95-1)

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Alternate Names: (2S,1'S,2'R)-2-(Carboxycyclopropyl)glycine
Application: L-CCG-IV is a potent small molecule agonist at the NMDA receptor
CAS Number: 117857-95-1
Purity: ≥97%
Molecular Weight: 159.14
Molecular Formula: C6H9NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

L-CCG-IV is a potent NMDA receptor agonist.


References

Shinozaki et al (1989) Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord. Br.J.Pharmacol. 98 1213. Kawai et al (1992) 2-Carboxycyclopropyl)glycine: binding, neurotoxicity and induction of intracellular free Ca2+ increase. Eur.J.Pharmacol. 211 195. Nakamura et al (1993) (2S,3S,4R)-2-(Carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology 32 833. Yamashita et al (1995) Inhibition by folded isomers of L-2-(carboxycyclopropyl)glycine of glutamate uptake via the human glutamate transporter hGluT-I. Eur.J.Pharmacol. 289 387.

Physical State :
Solid
Solubility :
Soluble in water (partly), and dilute aqueous base.
Storage :
Store at room temperature
Melting Point :
248.57° C (Predicted)
Boiling Point :
~414.1° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
Optical Activity :
α20/D +69.5°, c = 0.4 in water (lit.)
IC50 :
Glutamate NMDA receptor: IC50 = 5.2 nM (rat); Glutamate receptor ionotropic, AMPA: IC50 = 0.6 µM (rat); Glutamate receptor ionotropic, kainate: IC50 = 1.6 µM (rat)
pK Values :
pKa: 2.4 (Predicted), pKb: 9.83 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5310958
MDL Number :
MFCD00210186
SMILES :
C1C(C1C(=O)O)C(C(=O)O)N

Download SDS (MSDS)

Certificate of Analysis

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