L-Asparagine tert-butyl ester hydrochloride (CAS 63094-81-5)
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L-Asparagine tert-butyl ester hydrochloride is an esterified derivative of the amino acid L-asparagine, employed in peptide synthesis research. This compound is particularly useful in solid-phase peptide synthesis (SPPS) methodologies, where it is incorporated into growing peptide chains to introduce asparagine residues under conditions that minimize side reactions. The tert-butyl ester group serves as a protecting group, safeguarding the side chain′s amide functionality during the coupling reactions. Its hydrochloride salt form enhances solubility in reaction solvents, thereby improving its utility in various synthetic environments. Furthermore, researchers use this derivative to study the kinetics and mechanisms of peptide bond formation and to optimize the synthesis of complex peptides that may have biological activity or serve as tools for probing biological systems.
L-Asparagine tert-butyl ester hydrochloride (CAS 63094-81-5) References
- Synthesis of thiourea-tethered C-glycosyl amino acids via isothiocyanate-amine coupling. | Barghash, RF., et al. 2009. Org Biomol Chem. 7: 3319-30. PMID: 19641791
- Synthesis of Anthracene Conjugates of Truncated Antifreeze Protein Sequences: Effect of the End Group and Photocontrolled Dimerization on Ice Recrystallization Inhibition Activity. | Graham, B., et al. 2019. Biomacromolecules. 20: 4611-4621. PMID: 31714763
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Asparagine tert-butyl ester hydrochloride, 1 g | sc-235465 | 1 g | $146.00 |