Date published: 2025-9-5

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L-Ascorbic acid, free acid (CAS 50-81-7)

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Alternate Names:
Vitamin C
Application:
L-Ascorbic acid, free acid is also known as vitamin C
CAS Number:
50-81-7
Purity:
≥98%
Molecular Weight:
176.12
Molecular Formula:
C6H8O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-Ascorbic acid, free acid, known as Vitamin C, is an essential micronutrient that fulfills roles in various biological processes. Being water-soluble, it necessitates regular intake to sustain optimal health since the body does not store it. L-Ascorbic acid, free acid participates in numerous physiological and biochemical functions, including collagen synthesis, immune system support, and antioxidant defense. Moreover, it exhibits protective effects against the detrimental impact of radiation and oxygen radicals. L-Ascorbic Acid, Free Acid, a form of ascorbic acid, possesses distinctive properties such as promoting mineralization in osteoblasts, engaging in hydroxylation processes of proline and lysine, reducing Na+/Ca2+ exchange in cultured astrocytes, and modulating cyclic nucleotide levels in B and T cells. Furthermore, it has been observed to inhibit apoptosis in cultured rat ovarian follicles and exert inhibitory effects on T-type calcium channel CP α 1H. Additionally, it contributes to collagen production, which is vital for maintaining the structural integrity of the skin, bones, and other tissues. Furthermore, L-Ascorbic acid, free acid participates in the synthesis of neurotransmitters and hormones, and it contributes to the metabolism of cholesterol and fatty acids.


L-Ascorbic acid, free acid (CAS 50-81-7) References

  1. Topical L-ascorbic acid: percutaneous absorption studies.  |  Pinnell, SR., et al. 2001. Dermatol Surg. 27: 137-42. PMID: 11207686
  2. Biotechnological approaches for L-ascorbic acid production.  |  Hancock, RD. and Viola, R. 2002. Trends Biotechnol. 20: 299-305. PMID: 12062975
  3. L-ascorbic acid microencapsulated with polyacylglycerol monostearate for milk fortification.  |  Lee, JB., et al. 2004. Biosci Biotechnol Biochem. 68: 495-500. PMID: 15056878
  4. Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.  |  Valpuesta, V. and Botella, MA. 2004. Trends Plant Sci. 9: 573-7. PMID: 15564123
  5. Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics.  |  Elmore, AR. 2005. Int J Toxicol. 24 Suppl 2: 51-111. PMID: 16154915
  6. l-Ascorbic acid (vitamin C) supplementation to optimize health and reproduction in cattle.  |  Ranjan, R., et al. 2012. Vet Q. 32: 145-50. PMID: 23078207
  7. Industrial production of L-ascorbic Acid (vitamin C) and D-isoascorbic acid.  |  Pappenberger, G. and Hohmann, HP. 2014. Adv Biochem Eng Biotechnol. 143: 143-88. PMID: 24258144
  8. Potential Antitumor Activity of 2-O-α-d-Glucopyranosyl-6-O-(2-Pentylheptanoyl)-l-Ascorbic Acid.  |  Miura, K., et al. 2018. Int J Mol Sci. 19: PMID: 29439410
  9. Current challenges facing one-step production of l-ascorbic acid.  |  Wang, P., et al. 2018. Biotechnol Adv. 36: 1882-1899. PMID: 30031778
  10. Current studies on the enzymatic preparation 2-O-α-d-glucopyranosyl-l-ascorbic acid with cyclodextrin glycosyltransferase.  |  Tao, X., et al. 2019. Crit Rev Biotechnol. 39: 249-257. PMID: 30563366
  11. Effect of L-Ascorbic Acid on Nickel-Induced Alteration of Cardiovascular Pathophysiology in Wistar Rats.  |  Reddy, RC., et al. 2020. Biol Trace Elem Res. 195: 178-186. PMID: 31338802
  12. Topical delivery of l-ascorbic acid spanlastics for stability enhancement and treatment of UVB induced damaged skin.  |  Elhabak, M., et al. 2021. Drug Deliv. 28: 445-453. PMID: 33620008
  13. Polyphenols, L-Ascorbic Acid, and Antioxidant Activity in Wines from Rose Fruits (Rosa rugosa).  |  Cendrowski, A., et al. 2021. Molecules. 26: PMID: 33924795
  14. L-Ascorbic Acid and Curcumin Prevents Brain Damage Induced via Lead Acetate in Rats: Possible Mechanisms.  |  Alhusaini, AM., et al. 2022. Dev Neurosci. 44: 59-66. PMID: 34942627
  15. Synthesis of l-ascorbic acid-amino acid-norcantharidin conjugates and their biological activity evaluation in vitro.  |  Zhou, Y., et al. 2022. Nat Prod Res. 36: 5455-5461. PMID: 34965811

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-Ascorbic acid, free acid, 100 g

sc-202686
100 g
$45.00