L-AP3 (CAS 23052-80-4)
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L-AP3 is a selective antagonist of the metabotropic glutamate receptors (mGluRs), particularly influencing the group III mGluRs which are predominantly located pre-synaptically and involved in modulating neurotransmitter release in the central nervous system. By binding to these receptors, L-AP3 effectively inhibits the physiological response normally triggered by the natural ligand, glutamate, which is the principal excitatory neurotransmitter in the brain. This inhibition can significantly alter synaptic transmission and neural circuit function, making L-AP3 useful in neurophysiological research. Its utility lies in probing the roles of group III mGluRs in various neurophysiological processes, such as synaptic plasticity, which is fundamental for understanding learning and memory mechanisms. Additionally, by modulating glutamatergic signaling, L-AP3 contributes to the exploration of the pathophysiology of neurological conditions that are thought to involve dysfunctional glutamate neurotransmission, providing insights into potential molecular targets for intervention in such conditions.
L-AP3 (CAS 23052-80-4) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-AP3, 5 mg | sc-202201 | 5 mg | $45.00 | |||
L-AP3, 25 mg | sc-202201B | 25 mg | $203.00 |