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L-α-Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3) is a critical signaling phosphoinositide that acts as a secondary messenger in various cellular processes. It is synthesized from phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) through phosphorylation by phosphoinositide 3-kinase (PI3K). The chemical is pivotal in signal transduction pathways, notably the Akt pathway, by binding to pleckstrin homology (PH) domains of key proteins such as Akt, PDK1, and BTK. This binding promotes membrane recruitment and subsequent activation, facilitating cellular survival, proliferation, growth, and metabolism. In research, PtdIns-3,4,5-P3 is instrumental for studying the PI3K/Akt signaling pathway and its regulatory roles in cell cycle progression and apoptosis. It plays a vital role in understanding how dysregulation of these pathways can lead to pathological conditions. Additionally, its involvement in the regulation of small GTPases like Rac and Cdc42 provides insights into cytoskeletal dynamics, cell migration, and actin reorganization. Researchers use PtdIns-3,4,5-P3 analogs and inhibitors to delineate its signaling network, particularly in endocytosis, exocytosis, and vesicular trafficking. Recent studies also explore its spatial and temporal distribution in cells, revealing its role in localized signaling at specific membrane microdomains.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-α-Phosphatidylinositol-3,4,5-trisphosphate•7Na (PtdIns-3,4,5-P3), 100 µg | sc-221819 | 100 µg | $175.00 |