L-α-Phosphatidylcholine β-(pyren-1-yl)hexanoyl-γ-palmitoyl (CAS 103625-33-8)

L-α-Phosphatidylcholine β-(pyren-1-yl)hexanoyl-γ-palmitoyl, commonly abbreviated as PyrPC, is a unique derivative of phosphatidylcholine incorporating a pyrene moiety at the β-position of the hexanoyl chain and a palmitoyl group at the γ-position. In research, PyrPC has garnered attention for its utility as a fluorescent probe for studying lipid bilayer dynamics and membrane organization. The pyrene fluorophore exhibits characteristic excimer formation upon close proximity in lipid membranes, enabling the investigation of lipid bilayer structure and phase transitions. PyrPC has been extensively employed in fluorescence spectroscopy studies to explore lipid-protein interactions, membrane fusion processes, and lipid raft formation. Additionally, PyrPC-labeled liposomes have been utilized as model systems for investigating drug delivery mechanisms, assessing liposome stability, and evaluating the efficiency of drug encapsulation and release. The unique fluorescence properties of PyrPC make it a valuable tool for elucidating fundamental aspects of membrane biophysics and advancing research in areas such as membrane protein function, lipid bilayer dynamics, and nanomedicine development.