Molecular structure of L-817,818, CAS Number: 217480-27-8
L-817,818 (CAS 217480-27-8)
Application:
L-817,818 is a non-peptide somatostatin subtype-5 receptor agonist
CAS Number:
217480-27-8
Molecular Weight:
536.67
Molecular Formula:
C33H36N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
L-817,818 is a potent and selective non-peptide somatostatin subtype-5 receptor agonist. Inhibits growth hormone release from rat pituitary cells and insulin release from mouse pancreatic islets in vitro.
L-817,818 (CAS 217480-27-8) References
- Nonpeptidyl somatostatin agonists demonstrate that sst2 and sst5 inhibit stimulated growth hormone secretion from rat anterior pituitary cells. | Parmar, RM., et al. 1999. Biochem Biophys Res Commun. 263: 276-80. PMID: 10491284
- Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice. | Strowski, MZ., et al. 2000. Endocrinology. 141: 111-7. PMID: 10614629
- Identification and characterization of subtype selective somatostatin receptor agonists. | Rohrer, SP. and Schaeffer, JM. 2000. J Physiol Paris. 94: 211-5. PMID: 11087999
- SSTR2 mediates the somatostatin-induced increase in intracellular Ca(2+) concentration and insulin secretion in the presence of arginine vasopressin in clonal beta-cell HIT-T15. | Cheng, H., et al. 2002. Life Sci. 71: 927-36. PMID: 12084389
- Pharmacological characterisation of native somatostatin receptors in AtT-20 mouse tumour corticotrophs. | Cervia, D., et al. 2003. Br J Pharmacol. 139: 109-21. PMID: 12746229
- Different somatostatin receptor subtypes are operating in the brain of the teleost fish, Coris julis. | Madeo, M., et al. 2005. J Exp Zool A Comp Exp Biol. 303: 406-13. PMID: 15828016
- Internalization of sst2, sst3, and sst5 receptors: effects of somatostatin agonists and antagonists. | Cescato, R., et al. 2006. J Nucl Med. 47: 502-11. PMID: 16513620
- Activation of somatostatin receptor (sst 5) protects the rat retina from AMPA-induced neurotoxicity. | Kiagiadaki, F., et al. 2010. Neuropharmacology. 58: 297-303. PMID: 19576912
- Feeding responses to central administration of several somatostatin analogs in chicks. | Tachibana, T., et al. 2011. Comp Biochem Physiol A Mol Integr Physiol. 158: 47-51. PMID: 20826222
- Somatostatin regulates NHE8 protein expression via the ERK1/2 MAPK pathway in DSS-induced colitis mice. | Li, X., et al. 2016. Am J Physiol Gastrointest Liver Physiol. 311: G954-G963. PMID: 27686614
- Up-regulation of NHE8 by somatostatin ameliorates the diarrhea symptom in infectious colitis mice model. | Lei, X., et al. 2018. Korean J Physiol Pharmacol. 22: 269-275. PMID: 29719449
- Activation of somatostatin receptor 5 suppresses T-type Ca2+ channels through NO/cGMP/PKG signaling pathway in rat retinal ganglion cells. | Li, Q., et al. 2019. Neurosci Lett. 708: 134337. PMID: 31220522
- Somatostatin receptor 5-mediated modulation of outward K+ currents in rat retinal ganglion cells. | Wu, N., et al. 2020. Neuroreport. 31: 131-138. PMID: 31895741
- Neuroprotective effect of the somatostatin receptor 5 agonist L-817,818 on retinal ganglion cells in experimental glaucoma. | Zhang, Y., et al. 2021. Exp Eye Res. 204: 108449. PMID: 33465395
- Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. | Rohrer, SP., et al. 1998. Science. 282: 737-40. PMID: 9784130
Activator of:
SSTR5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-817,818, 10 mg | sc-204048 | 10 mg | $279.00 |