Molecular structure of L-765,314, CAS Number: 189349-50-6
L-765,314 (CAS 189349-50-6)
See product citations (3)
Alternate Names:
(2S)-4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-2-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperazinecarboxylic acid, phenylmethyl ester
Application:
L-765,314 is a potent and selective α1B-adrenoceptor antagonist
CAS Number:
189349-50-6
Purity:
≥95%
Molecular Weight:
522.60
Molecular Formula:
C27H34N6O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
L-765,314 is a potent and selective alpha1B-adrenoceptor antagonist. Alpha-1 adrenergic receptors are G protein-coupled receptors (GPCRs) involved in various physiological processes. L-765,314 is useful for studies that look into the roles of alpha-1 adrenergic signaling. The specificity of L-765,314 for the alpha-1 adrenergic receptor over other receptor subtypes allows for targeted investigations into the effects of alpha-1 adrenergic receptor blockade. Its use in experimental models can help identify the mechanisms of action of alpha-1 adrenergic receptors.
L-765,314 (CAS 189349-50-6) References
- The role of several alpha(1)- and alpha(2)-adrenoceptor subtypes mediating vasoconstriction in the canine external carotid circulation. | Willems, EW., et al. 2001. Br J Pharmacol. 132: 1292-8. PMID: 11250880
- Alpha1-adrenoceptor subtypes mediating vasoconstriction in the carotid circulation of anaesthetized pigs: possible avenues for antimigraine drug development. | Willems, EW., et al. 2001. Cephalalgia. 21: 110-9. PMID: 11422093
- Effects of L-765,314, a selective and potent alpha 1B-adrenoceptor antagonist, on periarterial nerve electrical stimulation-induced double-peaked constrictor responses in isolated dog splenic arteries. | Yang, XP. and Chiba, S. 2002. Jpn J Pharmacol. 89: 429-32. PMID: 12233824
- Alpha-1B adrenoceptors mediate neurogenic constriction in mesenteric arteries of normotensive and DOCA-salt hypertensive mice. | Pérez-Rivera, AA., et al. 2005. Auton Neurosci. 121: 64-73. PMID: 16095979
- Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus. | Hillman, KL., et al. 2007. J Pharmacol Exp Ther. 321: 1062-8. PMID: 17337632
- Smooth muscle alpha1D-adrenoceptors mediate phenylephrine-induced vasoconstriction and increases in endothelial cell Ca2+ in hamster cremaster arterioles. | Jackson, WF., et al. 2008. Br J Pharmacol. 155: 514-24. PMID: 18604236
- Pharmacological identification of α1- and α2-adrenoceptor subtypes involved in the vasopressor responses induced by ergotamine in pithed rats. | Villamil-Hernández, MT., et al. 2013. Eur J Pharmacol. 715: 262-9. PMID: 23707349
- Pharmacologically distinct phenotypes of α1B -adrenoceptors: variation in binding and functional affinities for antagonists. | Yoshiki, H., et al. 2014. Br J Pharmacol. 171: 4890-901. PMID: 24923551
- Identification of two novel α1-AR agonists using a high-throughput screening model. | Xu, F., et al. 2014. Molecules. 19: 12699-709. PMID: 25140448
- Involvement of α1B-adrenoceptors in the anti-immobility effect of imipramine in the tail suspension test. | Ribeiro, CA. and Pupo, AS. 2015. Eur J Pharmacol. 750: 39-42. PMID: 25617795
- The role of α1- and α2-adrenoceptor subtypes in the vasopressor responses induced by dihydroergotamine in ritanserin-pretreated pithed rats. | Rivera-Mancilla, E., et al. 2017. J Headache Pain. 18: 104. PMID: 29022279
- Contraction of Rat Cauda Epididymis Smooth Muscle to α1-Adrenoceptor Activation Is Mediated by α1A-Adrenoceptors. | Pacini, ESA., et al. 2018. J Pharmacol Exp Ther. 366: 21-28. PMID: 29685886
- L-765,314 Suppresses Melanin Synthesis by Regulating Tyrosinase Activity. | Kim, J., et al. 2019. Molecules. 24: PMID: 30795539
- α1B/D-adrenoceptors regulate chemokine receptor-mediated leukocyte migration via formation of heteromeric receptor complexes. | Enten, GA., et al. 2022. Proc Natl Acad Sci U S A. 119: e2123511119. PMID: 35537053
- Phenylephrine-Induced Contraction in Guinea Pig Thoracic Aorta Is Triggered by Stimulation of α1L-Adrenoceptors Functionally Coupled with Store-Operated Ca2+ Channels and Voltage-Dependent Ca2+ Channels. | Obara, K., et al. 2023. Biol Pharm Bull. 46: 309-319. PMID: 36724959
Inhibitor of:
Adenosine A2B-R, and alpha1B-AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-765,314, 5 mg | sc-493741 | 5 mg | $306.00 |