L 760735 CAS: 188923-01-5
MF: C26H28F7N5O2•HCl
MW: 611.98
A high affinity NK1 receptor antagonist.

L 760735 (CAS 188923-01-5)

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Alternate Names: 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine hydrochloride
Application: L 760735 is a high affinity NK1 receptor antagonist
CAS Number: 188923-01-5
Purity: ≥99%
Molecular Weight: 611.98
Molecular Formula: C26H28F7N5O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

L 760735 is a high-affinity NK1 reeptor antagonist (IC50 = 0.19 nM at human NK1 receptors. This compound is selective over NK2 and NK3 receptors. L 760735 exhibits anxiolytic and antidepressant-like effects.

Physical State :
Solid
Solubility :
Soluble to 30 mM in water and to 50 mM in DMSO
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9809076
SMILES :
C[[email protected]](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[[email protected]@H]2[[email protected]@H](N(CCO2)CC3=NNN=C3CN(C)C)C4=CC=C(C=C4)F.Cl

Download SDS (MSDS)

Certificate of Analysis

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