Molecular structure of L-748,337, CAS Number: 244192-94-7
L-748,337 (CAS 244192-94-7)
See product citations (4)
Alternate Names:
L-748,337 is known as a selective β3-adrenergic receptor antagonist.
Application:
L-748,337 is a selective competitive β3-adrenoceptor antagonist that can also inhibit cAMP accumulation in response to isoproterenol.
CAS Number:
244192-94-7
Purity:
≥98%
Molecular Weight:
497.61
Molecular Formula:
C26H31N3O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-748,337 is a competitive β3-adrenoceptor antagonist that displays selectivity over β1 and β2 receptors (Ki values are 4.0, 204 and 390 nM for β3-, β2- and β1-adrenoceptors respectively). L-748,337 inhibits cAMP accumulation in response to isoproterenol (IC50 = 6 nM). L-748,337 has been observed to couple with Gi to activate MAPK signaling. Additionally, L-748,337 can inhibit agonist-induced relaxation of smooth muscle, and agonist-stimulated lipolysis in rhesus monkey adipocytes.
L-748,337 (CAS 244192-94-7) References
- Enhanced inhibition of L-type Ca2+ current by beta3-adrenergic stimulation in failing rat heart. | Zhang, ZS., et al. 2005. J Pharmacol Exp Ther. 315: 1203-11. PMID: 16135702
- Nebivolol, a vasodilating selective beta(1)-blocker, is a beta(3)-adrenoceptor agonist in the nonfailing transplanted human heart. | Rozec, B., et al. 2009. J Am Coll Cardiol. 53: 1532-8. PMID: 19389564
- β3-Adrenergic receptor antagonist improves exercise performance in pacing-induced heart failure. | Masutani, S., et al. 2013. Am J Physiol Heart Circ Physiol. 305: H923-30. PMID: 23873794
- Functional involvement of β3-adrenergic receptors in melanoma growth and vascularization. | Dal Monte, M., et al. 2013. J Mol Med (Berl). 91: 1407-19. PMID: 23907236
- The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells. | Mason, RP., et al. 2013. BMC Pharmacol Toxicol. 14: 48. PMID: 24074014
- The new radioligand [(3)H]-L 748,337 differentially labels human and rat β3-adrenoceptors. | van Wieringen, JP., et al. 2013. Eur J Pharmacol. 720: 124-30. PMID: 24183974
- β3-adrenergic receptor activity modulates melanoma cell proliferation and survival through nitric oxide signaling. | Dal Monte, M., et al. 2014. Naunyn Schmiedebergs Arch Pharmacol. 387: 533-43. PMID: 24599317
- Design and synthesis of aryloxypropanolamine as β3-adrenergic receptor antagonist in cancer and lipolysis. | Jin, J., et al. 2018. Eur J Med Chem. 150: 757-770. PMID: 29574204
- Mirabegron, a β3-adrenoceptor agonist reduced platelet aggregation through cyclic adenosine monophosphate accumulation. | Mendes-Silvério, CB., et al. 2018. Eur J Pharmacol. 829: 79-84. PMID: 29654782
- Effects of β3-adrenergic receptor stimulation on the resting holding current of medial prefrontal cortex pyramidal neurons in young rats. | Grzelka, K., et al. 2019. Neurosci Lett. 698: 192-197. PMID: 30641111
- Telmisartan induces browning of fully differentiated white adipocytes via M2 macrophage polarization. | Jeon, EJ., et al. 2019. Sci Rep. 9: 1236. PMID: 30718686
- Desensitization of cAMP Accumulation via Human β3-Adrenoceptors Expressed in Human Embryonic Kidney Cells by Full, Partial, and Biased Agonists. | Okeke, K., et al. 2019. Front Pharmacol. 10: 596. PMID: 31263412
- Effect of β1 /β2 -adrenoceptor blockade on β3 -adrenoceptor activity in the rat cremaster muscle artery. | Saunders, SL., et al. 2021. Br J Pharmacol. 178: 1789-1804. PMID: 33506492
- The β3 Adrenergic Receptor Antagonist L-748,337 Attenuates Dobutamine-Induced Cardiac Inefficiency While Preserving Inotropy in Anesthetized Pigs. | Rødland, L., et al. 2021. J Cardiovasc Pharmacol Ther. 26: 714-723. PMID: 34551626
- Validation of Fenoterol to Study β2-Adrenoceptor Function in the Rat Urinary Bladder. | Erdogan, BR., et al. 2022. Pharmacology. 107: 116-121. PMID: 34781292
Inhibitor of:
β3Gn-T2, beta3-AR, GPR157, and PLC β3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-748,337, 10 mg | sc-204044 | 10 mg | $258.00 | |||
| US: Only available in the US | ||||||
L-748,337, 50 mg | sc-204044A | 50 mg | $1068.00 | |||
| US: Only available in the US | ||||||