Molecular structure of L-741,626, CAS Number: 81226-60-0
L-741,626 (CAS 81226-60-0)
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Alternate Names:
3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole
Application:
L-741,626 is a selective D2DR inhibitor
CAS Number:
81226-60-0
Purity:
≥98%
Molecular Weight:
340.85
Molecular Formula:
C20H21ClN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-741,626 is a selective D2DR inhibitor. L-741,626 acts selectively at the D2 receptor with such affinity that it can be used as a probe to determine if D2 receptors mediate the effects of compounds of interest. This approach was used to determine the dopamine receptor involved in PD 128907 agonism, where antagonism of the effects of PD 128907 by L-741,626 indicated a D2-mediated action.
L-741,626 (CAS 81226-60-0) References
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- Modulation of AMPA currents by D(1)-like but not D(2)-like receptors in spinal motoneurons. | Han, P. and Whelan, PJ. 2009. Neuroscience. 158: 1699-707. PMID: 19110039
- D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD. | Fan, X., et al. 2010. Neurobiol Dis. 37: 228-36. PMID: 19840852
- p-Hydroxyamphetamine causes prepulse inhibition disruptions in mice: contribution of dopamine neurotransmission. | Onogi, H., et al. 2010. Behav Brain Res. 214: 349-56. PMID: 20540968
- The dopamine D(2) receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth muscle. | Mizuta, K., et al. 2012. Am J Physiol Lung Cell Mol Physiol. 302: L316-24. PMID: 21964403
- Examining dopamine D3 receptor occupancy by antipsychotic drugs via [3H]7-OH-DPAT ex vivo autoradiography and its cross-validation via c-fos immunohistochemistry in the rat brain. | Davoodi, N., et al. 2014. Eur J Pharmacol. 740: 669-75. PMID: 24967534
- Drinking sucrose or saccharin enhances sensitivity of rats to quinpirole-induced yawning. | Serafine, KM., et al. 2015. Eur J Pharmacol. 764: 529-536. PMID: 26189020
- Response of colonic motility to dopaminergic stimulation is subverted in rats with nigrostriatal lesion: relevance to gastrointestinal dysfunctions in Parkinson's disease. | Levandis, G., et al. 2015. Neurogastroenterol Motil. 27: 1783-95. PMID: 26433214
- Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D2 and D3 Receptors. | Newton, CL., et al. 2016. PLoS One. 11: e0158808. PMID: 27379794
- Dopamine D3 autoreceptor inhibition enhances cocaine potency at the dopamine transporter. | McGinnis, MM., et al. 2016. J Neurochem. 138: 821-9. PMID: 27393374
- Dopamine D3 receptor-modulated neuroprotective effects of lisuride. | Kim, M., et al. 2017. Neuropharmacology. 117: 14-20. PMID: 28131770
- Ameliorative effect of chlorpromazine hydrochloride on visceral hypersensitivity in rats: possible involvement of 5-HT2A receptor. | Asano, T., et al. 2017. Br J Pharmacol. 174: 3370-3381. PMID: 28750135
- The D1/D2-like receptor antagonist flupentixol and the D2-like receptor antagonist L-741626 decrease operant responding for nicotine and food and locomotor activity in male and female rats. | Chellian, R., et al. 2023. J Psychopharmacol. 37: 216-228. PMID: 36680471
- 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. | Kulagowski, JJ., et al. 1996. J Med Chem. 39: 1941-2. PMID: 8642550
- Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626. | Bowery, BJ., et al. 1996. Br J Pharmacol. 119: 1491-7. PMID: 8968560
Inhibitor of:
D2DR, D4DR, and D5DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-741,626, 10 mg | sc-252936 | 10 mg | $114.00 |