Molecular structure of L-694,247, CAS Number: 137403-12-4
L-694,247 (CAS 137403-12-4)
Alternate Names:
2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine
Application:
L-694,247 is a highly potent and selective SR-1D agonist
CAS Number:
137403-12-4
Molecular Weight:
411.48
Molecular Formula:
C20H21N5O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
L-694,247 is a member of tryptamines. It is known to be a highly potent and selective serotonin (5-HT) receptor SR-1D agonist, as well as an activator of SR-1B. It is selective for 5-HT1D over the 5-HT1A, 5-HT1C, 5-HT1E, 5-HT2, and 5-HT3 receptors (Kis = 0.093, 2.29, 380, 2,187, 316, and >10,000 nM, respectively). L-694,247 inhibits adenylyl cyclase activity induced by forskolin and potassium-induced 5-HT release. It also induces a partial blockade of water intake.
L-694,247 (CAS 137403-12-4) References
- On the role of 5-HT1B/1D receptors in modulating transmission in a spinal reflex pathway in the decerebrated rabbit. | Ogilvie, J., et al. 1999. Br J Pharmacol. 128: 781-7. PMID: 10516662
- Hypothalamic paraventricular 5-hydroxytryptamine: receptor-specific inhibition of NPY-stimulated eating and energy metabolism. | Currie, PJ., et al. 2002. Pharmacol Biochem Behav. 71: 709-16. PMID: 11888562
- Vasodilator and vasoconstrictor responses induced by 5-hydroxytryptamine in the in situ blood autoperfused hindquarters of the anaesthetized rat. | Calama, E., et al. 2002. Naunyn Schmiedebergs Arch Pharmacol. 366: 110-6. PMID: 12122496
- 5-Hydroxytryptamine-induced vasodilator responses in the hindquarters of the anaesthetized rat, involve beta2-adrenoceptors. | Calama, E., et al. 2003. J Pharm Pharmacol. 55: 1371-8. PMID: 14607019
- In vivo effects of local activation and blockade of 5-HT1B receptors on globus pallidus neuronal spiking. | Querejeta, E., et al. 2005. Brain Res. 1043: 186-94. PMID: 15862532
- The role of endothelium-derived hyperpolarizing factor and cyclooxygenase pathways in the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in chronic sarpogrelate treated rats. | García-Pedraza, JÁ., et al. 2014. Eur J Pharmacol. 731: 80-7. PMID: 24675150
- Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats. | García-Pedraza, JÁ., et al. 2015. Clin Exp Pharmacol Physiol. 42: 640-7. PMID: 25854421
- 5-HT1D receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats. | García-Pedraza, JÁ., et al. 2015. Vascul Pharmacol. 72: 172-80. PMID: 26003124
- 5-HT2 receptor blockade exhibits 5-HT vasodilator effects via nitric oxide, prostacyclin and ATP-sensitive potassium channels in rat renal vasculature. | García-Pedraza, JA., et al. 2016. Vascul Pharmacol. 79: 51-59. PMID: 26586311
- 5-HT modulates the rat mesenteric vasopressor outflow by 5-HT1D sympatholytic receptors. | García-Pedraza, JÁ., et al. 2017. Clin Exp Pharmacol Physiol. 44: 1224-1231. PMID: 28771848
- Sumatriptan inhibits the electrophysiological activity of ASICs in rat trigeminal ganglion neurons. | Guo, L., et al. 2018. Eur J Pharmacol. 841: 98-103. PMID: 30336137
- Fluoxetine Treatment Decreases Cardiac Vagal Input and Alters the Serotonergic Modulation of the Parasympathetic Outflow in Diabetic Rats. | García-Domingo, M., et al. 2022. Int J Mol Sci. 23: PMID: 35628547
- Evidence for presynaptic location of inhibitory 5-HT1D beta-like autoreceptors in the guinea-pig brain cortex. | Bühlen, M., et al. 1996. Naunyn Schmiedebergs Arch Pharmacol. 353: 281-9. PMID: 8692282
- Effect of third ventricle administration of L-694,247, a selective 5-HT1D receptor agonist, on water intake in rats. | De Castro-e-Silva, E., et al. 1997. Pharmacol Biochem Behav. 57: 749-54. PMID: 9259002
- Characterization of prejunctional 5-HT1 receptors that mediate the inhibition of pressor effects elicited by sympathetic stimulation in the pithed rat. | Morán, A., et al. 1998. Br J Pharmacol. 123: 1205-13. PMID: 9559906
Activator of:
SR-1B, and SR-1D.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-694,247, 10 mg | sc-361223 | 10 mg | $195.00 | |||
L-694,247, 50 mg | sc-361223A | 50 mg | $803.00 |