Molecular structure of L-689,560, CAS Number: 139051-78-8
L-689,560 (CAS 139051-78-8)
Application:
L-689,560 is a potent antagonist at the glycine-NMDA receptor site
CAS Number:
139051-78-8
Molecular Weight:
380.2
Molecular Formula:
C17H15N3O3Cl2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-689,560 is a selective antagonist at the glycine-binding site of the NMDA receptor. The binding of a labeled [3H]L-689,560 compound to the glycine site of NMDA receptor is demonstrated to be modulated by polyamines, and [3H] L-689,560 is also suggested for use as a ligand in characterization of NMDA receptor during purification.
L-689,560 (CAS 139051-78-8) References
- Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain. | Foster, AC., et al. 1992. Mol Pharmacol. 41: 914-22. PMID: 1375317
- Characterization of the binding of [3H]L-689,560, an antagonist for the glycine site on the N-methyl-D-aspartate receptor, to rat brain membranes. | Grimwood, S., et al. 1992. Mol Pharmacol. 41: 923-30. PMID: 1375318
- 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor. | Leeson, PD., et al. 1992. J Med Chem. 35: 1954-68. PMID: 1534584
- Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor. | Leeson, PD., et al. 1991. J Med Chem. 34: 1243-52. PMID: 1826744
- Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling. | Minnella, AM., et al. 2018. Sci Rep. 8: 17522. PMID: 30504838
- Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists. | Rouzbeh, N., et al. 2023. J Gen Physiol. 155: PMID: 37078900
- Characterization of the solubilized NMDA receptor complex from rat brain with [3H]L-689,560, a glycine site antagonist. | Quirk, K., et al. 1994. Mol Membr Biol. 11: 17-21. PMID: 7912609
- Polyamines modulate [3H]L-689,560 binding to the glycine site of the NMDA receptor from rat brain. | Grimwood, S., et al. 1994. Eur J Pharmacol. 266: 43-50. PMID: 8137882
- (+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors. | Thomas, P., et al. 1993. J Neurochem. 60: 2308-11. PMID: 8492133
- Antagonist properties of eliprodil and other NMDA receptor antagonists at rat NR1A/NR2A and NR1A/NR2B receptors expressed in Xenopus oocytes. | Avenet, P., et al. 1997. Neurosci Lett. 223: 133-6. PMID: 9089691
Inhibitor of:
NMDA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-689,560, 1 mg | sc-202684 | 1 mg | $45.00 |