Date published: 2026-4-1

1-800-457-3801

SCBT Portrait Logo
Seach Input

L-655,238 (CAS 101910-24-1)

0.0(0)
Write a reviewAsk a question

Alternate Names:
REV-5901; α-pentyl-3-(2-quinolinylmethoxy)-benzenemethanol
Application:
L-655,238 is a potent and selective inhibitor of FLAP (5-LO-activating protein)
CAS Number:
101910-24-1
Purity:
≥98%
Molecular Weight:
335.4
Molecular Formula:
C22H25NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

L-655,238 is a compound of interest in the area of biochemistry and molecular biology, particularly in the study of enzyme inhibition. It is known to act as an inhibitor of the enzyme farnesyl protein transferase, which is involved in the post-translational modification of proteins through a process called prenylation. This modification is for the proper localization and function of various intracellular proteins. By investigating the effects of L-655,238 on this enzyme, researchers are able to gain valuable insights into the role of protein prenylation in cell signaling pathways and cellular growth mechanisms. The compound′s inhibitory activity also serves as a tool for exploring the potential role of farnesyl protein transferase in the life cycle of cells and its implications in the regulation of certain proteins that are pivotal for cell division and differentiation. Furthermore, the study of L-655,238 and its analogs can contribute to the understanding of the biochemical basis for diseases where protein prenylation plays a key role, thus aiding in the identification of novel targets for biochemical research.


L-655,238 (CAS 101910-24-1) References

  1. Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1.  |  Sjölinder, M., et al. 1999. J Lipid Res. 40: 439-46. PMID: 10064732
  2. An anti-platelet agent, OPC-29030, inhibits translocation of 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid production in human platelets.  |  Ozeki, Y., et al. 1999. Br J Pharmacol. 128: 1699-704. PMID: 10588925
  3. Novel effects of 5,8,11-eicosatriynoic acid, a lipoxygenase inhibitor, on Ca2+ mobilization in Madin Darby canine kidney cells.  |  Lee, KC., et al. 2001. Pharmacol Toxicol. 88: 20-6. PMID: 11169157
  4. 5-Lipoxygenase is required for proliferation of immature cerebellar granule neurons in vitro.  |  Uz, T., et al. 2001. Eur J Pharmacol. 418: 15-22. PMID: 11334860
  5. Functional coupling between secretory and cytosolic phospholipase A2 modulates tumor necrosis factor-alpha- and interleukin-1beta-induced NF-kappa B activation.  |  Anthonsen, MW., et al. 2001. J Biol Chem. 276: 30527-36. PMID: 11390371
  6. Platelet 12-lipoxygenase activation via glycoprotein VI: involvement of multiple signaling pathways in agonist control of H(P)ETE synthesis.  |  Coffey, MJ., et al. 2004. Circ Res. 94: 1598-605. PMID: 15142951
  7. Dietary gamma-linolenic acid modulates macrophage-vascular smooth muscle cell interactions. Evidence for a macrophage-derived soluble factor that downregulates DNA synthesis in smooth muscle cells.  |  Fan, YY., et al. 1995. Arterioscler Thromb Vasc Biol. 15: 1397-403. PMID: 7670954
  8. Role of 5'-lipoxygenase metabolites in the activation of peritoneal macrophages for tumoricidal function.  |  Hubbard, NE. and Erickson, KL. 1995. Cell Immunol. 160: 115-22. PMID: 7842477
  9. Leukotriene C4 modulation of muscarinic K+ current activation in bullfrog atrial myocytes.  |  Scherer, RW., et al. 1993. J Gen Physiol. 102: 125-41. PMID: 8376954
  10. The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.  |  Dreyer, EB. and Lipton, SA. 1995. Eur J Neurosci. 7: 2502-7. PMID: 8845955
  11. 5-Lipoxygenase metabolites of arachidonic acid regulate volume decrease by mudpuppy red blood cells.  |  Light, DB., et al. 1997. J Membr Biol. 158: 229-39. PMID: 9263885
  12. How opioids inhibit GABA-mediated neurotransmission.  |  Vaughan, CW., et al. 1997. Nature. 390: 611-4. PMID: 9403690
  13. Leukotriene B4 mediates histamine induction of NF-kappaB and IL-8 in human bronchial epithelial cells.  |  Aoki, Y., et al. 1998. Am J Physiol. 274: L1030-9. PMID: 9609743

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-655,238, 10 mg

sc-221799
10 mg
$122.00

L-655,238, 50 mg

sc-221799A
50 mg
$486.00