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L-655,238 is a potent and selective inhibitor of FLAP (5-LO-activating protein). L-655,238 is an inhibitor of CysLT1 Receptor.
5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors.: J.F. Evans, et al.; Mol. Pharmacol. 40, 22 (1991) FLAP: a novel drug target for inhibiting the synthesis of leukotrienes.: A.W. Ford-Hutchinson; Trends Pharmacol. Sci. 12, 68 (1991)
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