L-655,238 CAS: 101910-24-1
MF: C22H25NO2
MW: 335.4
A potent and selective inhibitor of FLAP (5-LO-activating protein).

L-655,238 (CAS 101910-24-1)

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Synonym: α-Pentyl-3-(2-quinolinylmethoxy)-benzenemethanol; REV-5901 para isomer
Application: A potent and selective inhibitor of FLAP (5-LO-activating protein)
CAS Number: 101910-24-1
Purity: 99%
Molecular Weight: 335.4
Molecular Formula: C22H25NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-655,238 is a potent and selective inhibitor of FLAP (5-LO-activating protein). L-655,238 is an inhibitor of CysLT1 Receptor.


References

5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors.: J.F. Evans, et al.; Mol. Pharmacol. 40, 22 (1991) FLAP: a novel drug target for inhibiting the synthesis of leukotrienes.: A.W. Ford-Hutchinson; Trends Pharmacol. Sci. 12, 68 (1991)

Physical State :
Solid
Solubility :
Soluble in ethanol (10 mg/ml), and DMSO (10 mg/ml).
Storage :
Store at room temperature
Melting Point :
92-93° C
Boiling Point :
501.83° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
Leukotriene synthesis : IC50 = 90 nM; 5-LO-activating protein: IC50 = 100 nM
pK Values :
pKb: 3.8 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9797817
MDL Number :
MFCD00211151
SMILES :
CCCCCC(C1=CC=C(C=C1)OCC2=NC3=CC=CC=C3C=C2)O

Download SDS (MSDS)

Certificate of Analysis

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