Molecular structure of L-371,257, CAS Number: 162042-44-6
L-371,257 (CAS 162042-44-6)
See product citations (2)
Alternate Names:
1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one
Application:
L-371,257 is a potent oxytocin receptor inhibitor
CAS Number:
162042-44-6
Molecular Weight:
507.59
Molecular Formula:
C28H33N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-371,257 is a potent and selective oxytocin receptor inhibitor. It displays >800-fold selectivity over human arginine vasopressin receptors V1a and V2. An analytical method utilizing high-performance liquid chromatography (HPLC) coupled with ultraviolet (UV) detection at a wavelength of 254 nm is used for its analysis.
L-371,257 (CAS 162042-44-6) References
- Nonpeptide oxytocin antagonists: analogs of L-371,257 with improved potency. | Williams, PD., et al. 1999. Bioorg Med Chem Lett. 9: 1311-6. PMID: 10340620
- Spontaneous contractions of myometrium from humans, non-human primate and rodents are sensitive to selective oxytocin receptor antagonism in vitro. | Wilson, RJ., et al. 2001. BJOG. 108: 960-6. PMID: 11563467
- A Gly/Ala switch contributes to high affinity binding of benzoxazinone-based non-peptide oxytocin receptor antagonists. | Hawtin, SR., et al. 2005. FEBS Lett. 579: 349-56. PMID: 15642343
- Differential contributions of vasopressin V1A and oxytocin receptors in the amygdala to pain-related behaviors in rats. | Cragg, B., et al. 2016. Mol Pain. 12: PMID: 27837170
- Downregulation of Oxytocin Receptor Decreases the Length of Projections Stimulated by Retinoic Acid in the U-87MG Cells. | Lestanova, Z., et al. 2017. Neurochem Res. 42: 1006-1014. PMID: 27995495
- Neurite Outgrowth Stimulated by Oxytocin Is Modulated by Inhibition of the Calcium Voltage-Gated Channels. | Zatkova, M., et al. 2018. Cell Mol Neurobiol. 38: 371-378. PMID: 28493233
- Projection length stimulated by oxytocin is modulated by the inhibition of calcium signaling in U-87MG cells. | Zatkova, M., et al. 2018. J Neural Transm (Vienna). 125: 1847-1856. PMID: 30269165
- Relevance of number and physiological status of conspecifics in preventing stress-induced decreases in newly proliferated cells and neuroblasts. | Sun, LH., et al. 2019. Psychopharmacology (Berl). 236: 3329-3339. PMID: 31201477
- Oxytocin induces intracellular Ca2+ release in cardiac fibroblasts from neonatal rats. | Ali, II., et al. 2019. Cell Calcium. 84: 102099. PMID: 31614270
- Cell proliferation and anti-oxidant effects of oxytocin and oxytocin receptors: role of extracellular signal-regulating kinase in astrocyte-like cells. | Alanazi, MM., et al. 2020. Endocr Regul. 54: 172-182. PMID: 32857718
- 1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist. | Williams, PD., et al. 1995. J Med Chem. 38: 4634-6. PMID: 7473590
- Progress in the development of oxytocin antagonists for use in preterm labor. | Pettibone, DJ., et al. 1995. Adv Exp Med Biol. 395: 601-12. PMID: 8714024
- Nonpeptide oxytocin antagonists: potent, orally bioavailable analogs of L-371,257 containing a 1-R-(pyridyl)ethyl ether terminus. | Kuo, MS., et al. 1998. Bioorg Med Chem Lett. 8: 3081-6. PMID: 9873680
Inhibitor of:
AVP, and Oxytocin Receptor.Activator of:
Oxytocin-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-371,257, 10 mg | sc-204038 | 10 mg | $516.00 | |||
| US: Only available in the US | ||||||