L-368,899 hydrochloride is a potent, non-peptide oxytocin receptor antagonist. L-368,899 hydrochloride has shown a 40-fold selectivity over vasopressin V1a and V2 receptors. L-368,899 hydrochloride has been shown to antagonize oxytocin-induced uterine contractions in vitro. L-368,899 hydrochloride is a useful tool for investigating the role of oxytocin, and studies in primates have shown L-368,899 hydrochloride to reduce a number of behaviours such as food sharing, sexual activity and caring for infants. L-368,899 hydrochloride is also known as L-368899 free base, (S)-2-amino-N-((1S,2S,4R)-7,7-dimethyl-1-((4-o-tolylpiperazin-1-ylsulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-4-(methylsulfonyl)butanamide, and 1-(((7,7-dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo[2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine.
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Can you give me an estimate for supply of 5g L368,899 manufactured to GMP standard for use in man
Asked by: Mark T
Thank you for your question. Our products are for research use only and are not made GMP food grade. This product can not be used for human consumption in any way.
Answered by: Tech Service
Date published: 2019-01-16
Can this product be stored in solution?
Asked by: hawkeye11
Thank you for your question.
In regards to L-368,899 hydrochloride, sc-204037, standard protocol is to make a solution for the amount needed prior to use. If a product must be stored in solution, then small one use aliquots stored at -20°C. Avoid freeze thaw cycles and use as soon as possible.
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