Molecular structure of L-368,899 hydrochloride, CAS Number: 148927-60-0
L-368,899 hydrochloride (CAS 148927-60-0)
See product citations (5)
Alternate Names:
L-368,899 hydrochloride is also known as L-368899 free base.
Application:
L-368,899 hydrochloride is a non-peptide, selective Oxytocin Receptor antagonist, with good selectivity over related vasopressin receptors.
CAS Number:
148927-60-0
Purity:
>97%
Molecular Weight:
591.22
Molecular Formula:
C26H42N4O5S2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-368,899 hydrochloride is a selective and potent non-peptide antagonist of the oxytocin receptor. It functions by competitively binding to the oxytocin receptor, preventing the binding of oxytocin and inhibiting its downstream signaling pathways. L-368,899 Hydrochloride′s mechanism of action involves blocking the effects of oxytocin on smooth muscle contraction. By interfering with oxytocin signaling, L-368,899 hydrochloride can be used to study the physiological and behavioral effects of oxytocin in various experimental models. Its ability to specifically target the oxytocin receptor may be valuable for investigating the role of oxytocin in social behavior, reproductive physiology, and other biological processes.
L-368,899 hydrochloride (CAS 148927-60-0) References
- Prevention of cannabinoid withdrawal syndrome by lithium: involvement of oxytocinergic neuronal activation. | Cui, SS., et al. 2001. J Neurosci. 21: 9867-76. PMID: 11739594
- Attenuation of PGF2alpha release in ewes infused with the oxytocin antagonist L-368,899. | Mann, GE., et al. 2003. Domest Anim Endocrinol. 25: 255-62. PMID: 14550509
- Discovery and development of a new class of potent, selective, orally active oxytocin receptor antagonists. | Quattropani, A., et al. 2005. J Med Chem. 48: 7882-905. PMID: 16302826
- Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. | Dölen, G., et al. 2013. Nature. 501: 179-84. PMID: 24025838
- An eye tracking system for monitoring face scanning patterns reveals the enhancing effect of oxytocin on eye contact in common marmosets. | Kotani, M., et al. 2017. Psychoneuroendocrinology. 83: 42-48. PMID: 28586711
- Oxytocin inhibits the rat medullary dorsal horn Sp5c/C1 nociceptive transmission through OT but not V1A receptors. | García-Boll, E., et al. 2018. Neuropharmacology. 129: 109-117. PMID: 29169960
- Oxytocin-dependent reopening of a social reward learning critical period with MDMA. | Nardou, R., et al. 2019. Nature. 569: 116-120. PMID: 30944474
- Effects of oxytocin receptor antagonism on social function and corticosterone release after adolescent social instability in male rats. | Hodges, TE., et al. 2019. Horm Behav. 116: 104579. PMID: 31449812
- Oxytocin Receptors Regulate Social Preference in Zebrafish. | Landin, J., et al. 2020. Sci Rep. 10: 5435. PMID: 32214126
- The Rostral Agranular Insular Cortex, a New Site of Oxytocin to Induce Antinociception. | Gamal-Eltrabily, M., et al. 2020. J Neurosci. 40: 5669-5680. PMID: 32571836
- Cesarean section delivery is a risk factor of autism-related behaviors in mice. | Nagano, M., et al. 2021. Sci Rep. 11: 8883. PMID: 33903690
- Activation of hypothalamic oxytocin neurons reduces binge-like alcohol drinking through signaling at central oxytocin receptors. | King, CE., et al. 2021. Neuropsychopharmacology. 46: 1950-1957. PMID: 34127796
- Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking. | Giannotti, G., et al. 2022. Transl Psychiatry. 12: 432. PMID: 36195606
- 1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo [2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperaz ine (L-368,899): an orally bioavailable, non-peptide oxytocin antagonist with potential utility for managing preterm labor. | Williams, PD., et al. 1994. J Med Chem. 37: 565-71. PMID: 8126695
Inhibitor of:
AVP Receptor V1a, CKLF, Oxytocin Receptor, and Oxytocin-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-368,899 hydrochloride, 1 mg | sc-204037 | 1 mg | $155.00 | |||
| US: Only available in the US | ||||||
L-368,899 hydrochloride, 10 mg | sc-204037A | 10 mg | $327.00 | |||
| US: Only available in the US | ||||||