L-368,899 hydrochloride CAS: 148927-60-0
MF: C26H42N4O5S2•HCl
MW: 591.22

L-368,899 hydrochloride (CAS 148927-60-0)

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Alternate Names: L-368,899 hydrochloride is also known as L-368899 free base.
Application: L-368,899 hydrochloride is a non-peptide, selective Oxytocin Receptor antagonist, with good selectivity over related vasopressin receptors.
CAS Number: 148927-60-0
Purity: >97%
Molecular Weight: 591.22
Molecular Formula: C26H42N4O5S2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-368,899 hydrochloride is a potent, non-peptide oxytocin receptor antagonist. L-368,899 hydrochloride has shown a 40-fold selectivity over vasopressin V1a and V2 receptors. L-368,899 hydrochloride has been shown to antagonize oxytocin-induced uterine contractions in vitro. L-368,899 hydrochloride is a useful tool for investigating the role of oxytocin, and studies in primates have shown L-368,899 hydrochloride to reduce a number of behaviours such as food sharing, sexual activity and caring for infants. L-368,899 hydrochloride is also known as L-368899 free base, (S)-2-amino-N-((1S,2S,4R)-7,7-dimethyl-1-((4-o-tolylpiperazin-1-ylsulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-4-(methylsulfonyl)butanamide, and 1-(((7,7-dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo[2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine.


References

1. Williams, P.D., et al. 1994. J. Med. Chem. 37: 565-571. PMID: 8126695

2. Cui, S.S., et al. 2001. J. Neurosci. 21: 9867-9876. PMID: 11739594

3. Mann, G.E., et al. 2003. Domest. Anim. Endocrinol. 25: 255-262. PMID: 14550509

4. Quattropani, A., et al. 2005. J. Med. Chem. 48: 7882-7905. PMID: 16302826

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Store at -20° C
Boiling Point :
794.1° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
Optical Activity :
α20D +27, c = 1 in methanol
IC50 :
Oxytocin receptor: IC50 = 8.9 nM; AVP Receptor V1a: IC50 = 370 nM; AVP Receptor V2: IC50 = 570 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
56972193
MDL Number :
MFCD09753328
SMILES :
CC1=CC=CC=C1N2CCN(CC2)S(=O)(=O)C[[email protected]@]34CC[[email protected]@H](C3(C)C)C[[email protected]@H]4NC(=O)[[email protected]](CCS(=O)(=O)C)N.Cl

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Certificate of Analysis

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Can you give me an estimate for supply of 5g L368,899 manufactured to GMP standard for use in man

Asked by: Mark T
Thank you for your question. Our products are for research use only and are not made GMP food grade. This product can not be used for human consumption in any way.
Answered by: Tech Service
Date published: 2019-01-16

Can this product be stored in solution?

Asked by: hawkeye11
Thank you for your question. In regards to L-368,899 hydrochloride, sc-204037, standard protocol is to make a solution for the amount needed prior to use. If a product must be stored in solution, then small one use aliquots stored at -20°C. Avoid freeze thaw cycles and use as soon as possible.
Answered by: TechService7
Date published: 2016-12-23
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