Molecular structure of L-161,982, CAS Number: 147776-06-5
L-161,982 (CAS 147776-06-5)
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Alternate Names:
N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide
Application:
L-161,982 is an EP4 receptor antagonist
CAS Number:
147776-06-5
Purity:
>99%
Molecular Weight:
654.72
Molecular Formula:
C32H29F3N4O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-161,982 is an EP4 receptor antagonist that is selective over all other members of the prostanoid receptor family (Ki values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μM for human EP4, TP, EP3, DP, FP, IP, EP1 and EP2 receptors respectively).
L-161,982 (CAS 147776-06-5) References
- Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2). | Machwate, M., et al. 2001. Mol Pharmacol. 60: 36-41. PMID: 11408598
- Activation of EP4 receptors contributes to prostaglandin E2-mediated stimulation of renal sensory nerves. | Kopp, UC., et al. 2004. Am J Physiol Renal Physiol. 287: F1269-82. PMID: 15292051
- Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia. | Oliva, P., et al. 2006. Eur J Pharmacol. 530: 40-7. PMID: 16360148
- Lipopolysaccharide induces epithelium- and prostaglandin E(2)-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase (COX)-1 and COX-2. | Balzary, RW. and Cocks, TM. 2006. J Pharmacol Exp Ther. 317: 806-12. PMID: 16464966
- The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. | Cherukuri, DP., et al. 2007. Exp Cell Res. 313: 2969-79. PMID: 17631291
- Role of prostaglandins in spinal transmission of the exercise pressor reflex in decerebrated rats. | Stone, AJ., et al. 2014. Neuroscience. 277: 26-35. PMID: 25003710
- The EP4 antagonist, L-161,982, induces apoptosis, cell cycle arrest, and inhibits prostaglandin E2-induced proliferation in oral squamous carcinoma Tca8113 cells. | Li, X., et al. 2017. J Oral Pathol Med. 46: 991-997. PMID: 28342204
- Prostaglandin E2 Receptor Antagonist with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus. | Ikeh, MAC., et al. 2018. Antimicrob Agents Chemother. 62: PMID: 29263068
- EP4 as a Negative Prognostic Factor in Patients with Vulvar Cancer. | Buchholz, A., et al. 2021. Cancers (Basel). 13: PMID: 33808776
- Inhibition of rat locus coeruleus neurons by prostaglandin E2 EP3 receptors: pharmacological characterization ex vivo. | Nazabal, A., et al. 2023. Front Pharmacol. 14: 1290605. PMID: 38035000
Inhibitor of:
EP4.Activator of:
EP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-161,982, 10 mg | sc-203436 | 10 mg | $296.00 |