Molecular structure of L-(+)-Penicillamine, CAS Number: 1113-41-3
L-(+)-Penicillamine (CAS 1113-41-3)
Alternate Names:
L-Penicillamine
CAS Number:
1113-41-3
Molecular Weight:
149.21
Molecular Formula:
C5H11NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-(+)-Penicillamine is a chiral compound that functions as a chelating agent in experimental applications. It acts by forming stable complexes with heavy metal ions, such as copper and lead, through the thiol group in its structure. This chelation process effectively removes these metal ions from biological systems, preventing their harmful effects on cellular processes. L-(+)-Penicillamine may inhibit the formation of disulfide bonds in proteins, which can alter their structure and function. L-(+)-Penicillamine′s mechanism of action involves disrupting the normal formation of these bonds, leading to potential changes in protein conformation and activity.
L-(+)-Penicillamine (CAS 1113-41-3) References
- Enantiomeric reversed-phase high-performance liquid chromatography resolution of D-/L-penicillamine after spirocyclization with ninhydrin and by using copper(II)-L-proline complex as a chiral selector in the mobile phase. | Sotgia, S., et al. 2008. J Chromatogr A. 1205: 90-3. PMID: 18723178
- Separation and determination of chiral composition in penicillamine tablets by capillary electrophoresis in a broad pH range. | Song, L., et al. 2012. Electrophoresis. 33: 2056-63. PMID: 22806473
- Bio-inspired nitrile hydration by peptidic ligands based on L-cysteine, L-methionine or L-penicillamine and pyridine-2,6-dicarboxylic acid. | Byrne, C., et al. 2014. Molecules. 19: 20751-67. PMID: 25514220
- Circular dichroism sensor based on cadmium sulfide quantum dots for chiral identification and detection of penicillamine. | Ngamdee, K., et al. 2015. Anal Chim Acta. 898: 93-100. PMID: 26526914
- S-Methylation of D- and L-penicillamine by human erythrocyte membrane thiol methyltransferase. | Keith, RA., et al. 1985. Drug Metab Dispos. 13: 669-76. PMID: 2867869
- The influence of penicillamine/cysteine mutation on the metal complexes of peptides. | Grenács, Á., et al. 2017. Dalton Trans. 46: 13472-13481. PMID: 28951904
- Homochiral fluorescence responsive molecularly imprinted polymer: Highly chiral enantiomer resolution and quantitative detection of L-penicillamine. | Zhang, Y., et al. 2021. J Hazard Mater. 412: 125249. PMID: 33548789
- Nano-scale minerals in-situ supporting CeO2 nanoparticles for off-on colorimetric detection of L-penicillamine and Cu2+ ion. | Lian, J., et al. 2022. J Hazard Mater. 433: 128766. PMID: 35364537
- A smartphone-assisted down/up-conversion dual-mode ratiometric fluorescence sensor for visual detection of mercury ions and l-penicillamine. | Tang, K., et al. 2023. Sci Total Environ. 856: 159073. PMID: 36179841
- DNA-Immobilized Special Conformation Recognition of L-Penicillamine Using a Chiral Molecular Imprinting Technique. | Zhang, L., et al. 2022. Polymers (Basel). 14: PMID: 36236082
- Mutagenicity of cysteine and penicillamine and its enantiomeric selectivity. | Glatt, H. and Oesch, F. 1985. Biochem Pharmacol. 34: 3725-8. PMID: 3902028
- Antivitamin B6 activity of L-penicillamine in Escherichia coli. | Yamada, R. 1983. Acta Vitaminol Enzymol. 5: 73-81. PMID: 6346839
- Quantitative determination of small amounts of L-penicillamine in D-penicillamine after desulfurization with Raney nickel. | Lodemann, E., et al. 1980. Arzneimittelforschung. 30: 395-7. PMID: 7387748
- High-performance liquid chromatographic separation of penicillamine enantiomers labelled with N-[4-(6-dimethylamino-2-benzofuranyl)phenyl] maleimide on a chiral stationary phase. | Nakashima, K., et al. 1995. Biomed Chromatogr. 9: 90-3. PMID: 7795392
- Purification and characterization of NAD:Penicillamine ADP transferase from Bacillus sphaericus. A novel NAD-dependent enzyme catalyzing phosphoramide bond formation. | Yanagidani, J., et al. 1999. J Biol Chem. 274: 795-800. PMID: 9873018
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-(+)-Penicillamine, 1 g | sc-257643 | 1 g | $56.00 | |||
L-(+)-Penicillamine, 5 g | sc-257643A | 5 g | $141.00 |