Date published: 2026-5-14

1-800-457-3801

SCBT Portrait Logo
Seach Input

Kyotorphin (CAS 70904-56-2)

0.0(0)
Write a reviewAsk a question

CAS Number:
70904-56-2
Molecular Weight:
337.4
Molecular Formula:
C15H23N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Kyotorphin is a dipeptide that has garnered research interest in the field of neuroscience due to its ability to modulate pain perception. It is studied for its interaction with specific receptors in the central nervous system and its potential role in the modulation of endogenous pain control pathways. Researchers utilize Kyotorphin to understand the mechanisms of neuropeptide action and neurotransmitter release, which are fundamental processes in neuronal communication. In addition, this compound is involved in studies focusing on the regulation of opioid receptors, contributing to the broader comprehension of how these receptors influence analgesic pathways. Kyotorphin is also a subject of interest in peptide chemistry, where its stability and resistance to enzymatic degradation are examined to inform the design of peptide-based compounds with enhanced bioactivity. The compound′s influence on the blood-brain barrier permeability is another area of study, which is relevant for investigating the transport of biologically active peptides into the central nervous system.


Kyotorphin (CAS 70904-56-2) References

  1. Kyotorphin suppresses proliferation and Ca2+ signaling in brown preadipocytes.  |  Bronnikov, GE., et al. 2006. Bull Exp Biol Med. 141: 223-5. PMID: 16984102
  2. Kyotorphin transport and metabolism in rat and mouse neonatal astrocytes.  |  Xiang, J., et al. 2010. Brain Res. 1347: 11-8. PMID: 20537989
  3. The mechanisms and quantification of the selective permeability in transport across biological barriers: the example of kyotorphin.  |  Serrano, ID., et al. 2014. Mini Rev Med Chem. 14: 99-110. PMID: 24456269
  4. The kyotorphin (tyrosine-arginine) receptor and a selective reconstitution with purified Gi, measured with GTPase and phospholipase C assays.  |  Ueda, H., et al. 1989. J Biol Chem. 264: 3732-41. PMID: 2537290
  5. Anti-inflammatory, analgesic and antioxidant activities of novel kyotorphin-nitroxide hybrid molecules.  |  Bi, W., et al. 2016. Bioorg Med Chem Lett. 26: 2005-13. PMID: 26961795
  6. Pharmacological Potential of the Endogenous Dipeptide Kyotorphin and Selected Derivatives.  |  Perazzo, J., et al. 2016. Front Pharmacol. 7: 530. PMID: 28127286
  7. Tyrosyl-tRNA synthetase: A potential kyotorphin synthetase in mammals.  |  Tsukahara, T., et al. 2018. Peptides. 101: 60-68. PMID: 29289698
  8. Antifungal and anti-biofilm activity of designed derivatives from kyotorphin.  |  Martins de Andrade, V., et al. 2020. Fungal Biol. 124: 316-326. PMID: 32389294
  9. Review of Kyotorphin Research: A Mysterious Opioid Analgesic Dipeptide and Its Molecular, Physiological, and Pharmacological Characteristics.  |  Ueda, H. 2021. Front Med Technol. 3: 662697. PMID: 35047919
  10. Kyotorphin (tyrosine-arginine) synthetase in rat brain synaptosomes.  |  Ueda, H., et al. 1987. J Biol Chem. 262: 8165-73. PMID: 3597366
  11. How is kyotorphin (Tyr-Arg) generated in the brain?  |  Ueda, H., et al. 1985. Neuropeptides. 5: 525-8. PMID: 4000421
  12. Kyotorphin synthetase activity in rat adrenal glands and spinal cord.  |  Kawabata, A., et al. 1996. Peptides. 17: 407-11. PMID: 8735966
  13. Kyotorphin (L-tyrosyl-L-arginine) as a possible substrate for inducible nitric oxide synthase in rat glial cells.  |  Arima, T., et al. 1996. Neurosci Lett. 212: 1-4. PMID: 8823748

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Kyotorphin, 5 mg

sc-471514
5 mg
$152.00