Molecular structure of Kynurenic Acid-d5, CAS Number: 350820-13-2
Kynurenic Acid-d5 (CAS 350820-13-2)
See product citations (3)
CAS Number:
350820-13-2
Molecular Weight:
194.20
Molecular Formula:
C10H2D5NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Kynurenic Acid-d5 has neuroactive activity.Kynurenic acid-d5 is a synthetic derivative of kynurenic acid. Kynurenic acid-d5 is intended for use as an internal standard for the quantification of kynurenic acidby GC- or LC-MS. Kynurenic acid is an active metabolite of tryptophan. It is formed from tryptophan via a kynurenine intermediate by kynurenine aminotransferases (KATs). Kynurenic acid is an antagonist of the NMDA and AMPA receptors as well as α7 nicotinic acetylcholine receptors (nAChRs EC50s = 235, 101, and 7 µM, respectively). It is also an agonist of the aryl hydrocarbon receptor (AhR) and G protein-coupled receptor 35 (GPR35 EC50s = 1.4 and 39 µM, respectively).
Kynurenic Acid-d5 (CAS 350820-13-2) References
- Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms. | Schefold, JC., et al. 2009. Nephrol Dial Transplant. 24: 1901-8. PMID: 19155537
- A liquid chromatography - tandem mass spectrometry method to measure a selected panel of uremic retention solutes derived from endogenous and colonic microbial metabolism. | de Loor, H., et al. 2016. Anal Chim Acta. 936: 149-56. PMID: 27566350
- A Simple HPLC-MS/MS Method for Determination of Tryptophan, Kynurenine and Kynurenic Acid in Human Serum and its Potential for Monitoring Antidepressant Therapy. | Hu, LJ., et al. 2017. J Anal Toxicol. 41: 37-44. PMID: 27590037
- A mass spectrometric method for quantification of tryptophan-derived uremic solutes in human serum. | Zhang, A., et al. 2017. J Biol Methods. 4: PMID: 29707597
- Development and validation of a UHPLC-MS/MS method for measurement of a gut-derived uremic toxin panel in human serum: An application in patients with kidney disease. | Prokopienko, AJ., et al. 2019. J Pharm Biomed Anal. 174: 618-624. PMID: 31276982
- Longitudinal relationship of amino acids and indole metabolites with long-term body mass index and cardiometabolic risk markers in young individuals. | Oluwagbemigun, K., et al. 2020. Sci Rep. 10: 6399. PMID: 32286421
- Quantification of free and protein bound uremic toxins in human serum by LC-MS/MS: Comparison of rapid equilibrium dialysis and ultrafiltration. | Fabresse, N., et al. 2020. Clin Chim Acta. 507: 228-235. PMID: 32371217
- Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression. | Parajuli, G., et al. 2021. Cancer Immunol Res. 9: 862-876. PMID: 34006522
- Skeletal myopathy in CKD: a comparison of adenine-induced nephropathy and 5/6 nephrectomy models in mice. | Kim, K., et al. 2021. Am J Physiol Renal Physiol. 321: F106-F119. PMID: 34121452
- Untargeted metabolomics and transcriptomics identified glutathione metabolism disturbance and PCS and TMAO as potential biomarkers for ER stress in lung. | Wang, Z., et al. 2021. Sci Rep. 11: 14680. PMID: 34282162
- An Investigation into the Temporal Reproducibility of Tryptophan Metabolite Networks Among Healthy Adolescents. | Oluwagbemigun, K., et al. 2021. Int J Tryptophan Res. 14: 11786469211041376. PMID: 34594109
- Branched-Chain and Aromatic Amino Acids Related to Visceral Adipose Tissue Impact Metabolic Health Risk Markers. | Orozco-Ruiz, X., et al. 2022. J Clin Endocrinol Metab. 107: e2896-e2905. PMID: 35325166
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Kynurenic Acid-d5, 2.5 mg | sc-470916 | 2.5 mg | $385.00 | |||
Kynurenic Acid-d5, 5 mg | sc-470916A | 5 mg | $676.00 | |||
Kynurenic Acid-d5, 10 mg | sc-470916B | 10 mg | $1196.00 |