KV1.1 Antibody (2D8): sc-293345
- KV1.1 Antibody (2D8) is a mouse monoclonal IgG2a κ KV1.1 antibody provided at 100 µg/ml
- raised against amino acids 410-495 of KV1.1 of human origin
- recommended for detection of KV1.1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for KV1.1 Antibody (2D8). This work is in progress.
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KV1.1 Antibody (2D8) is a mouse monoclonal IgG2a kappa light chain antibody that detects KV1.1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-KV1.1 antibody (2D8) is available as the non-conjugated format. KV1.1 protein plays a crucial role in the functioning of voltage-gated potassium channels, which are essential for the repolarization of action potentials in neurons and muscle cells. These channels are vital for maintaining electrical excitability of cells, influencing processes such as muscle contraction and neurotransmitter release. KV gene family, which includes over 30 genes, encodes subunits that form potassium channels, and diverse gating and permeation properties are critical for precise regulation of cellular excitability. KV1.1 protein specifically forms tetramers with other KVα subunits and can interact with KVβ subunits, which modulate channel gating behavior. Understanding interactions and regulatory mechanisms of KV1.1 is important for elucidating roles in various physiological processes and potential pathologies, including neurological disorders.
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KV1.1 Antibody (2D8) References:
- Subunit composition of Kv1 channels in human CNS. | Coleman, SK., et al. 1999. J Neurochem. 73: 849-58. PMID: 10428084
- Subunit composition determines Kv1 potassium channel surface expression. | Manganas, LN. and Trimmer, JS. 2000. J Biol Chem. 275: 29685-93. PMID: 10896669
- The brain Kv1.1 potassium channel: in vitro and in vivo studies on subunit assembly and posttranslational processing. | Deal, KK., et al. 1994. J Neurosci. 14: 1666-76. PMID: 8126562
- Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain. | Veh, RW., et al. 1995. Eur J Neurosci. 7: 2189-205. PMID: 8563969
- Beta subunits promote K+ channel surface expression through effects early in biosynthesis. | Shi, G., et al. 1996. Neuron. 16: 843-52. PMID: 8608002
- Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes. | Rhodes, KJ., et al. 1997. J Neurosci. 17: 8246-58. PMID: 9334400
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KV1.1 Antibody (2D8) | sc-293345 | 100 µg/ml | $316.00 |