Kurtoxin
Molecular Weight:
7386.36
Molecular Formula:
C324H478N94O90S8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Kurtoxin is a compound found in scorpion toxin, and is a T-type Ca2+ channel blocker.
Kurtoxin References
- Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin. | Chuang, RS., et al. 1998. Nat Neurosci. 1: 668-74. PMID: 10196582
- CaV2.2 and CaV2.3 (N- and R-type) Ca2+ channels in depolarization-evoked entry of Ca2+ into mouse sperm. | Wennemuth, G., et al. 2000. J Biol Chem. 275: 21210-7. PMID: 10791962
- Low voltage activated calcium channels: from genes to function. | Lacinová, L., et al. 2000. Gen Physiol Biophys. 19: 121-36. PMID: 11156438
- Kurtoxin, a gating modifier of neuronal high- and low-threshold ca channels. | Sidach, SS. and Mintz, IM. 2002. J Neurosci. 22: 2023-34. PMID: 11896142
- Discovery of potent T-type calcium channel blocker. | Seo, HN., et al. 2007. Bioorg Med Chem Lett. 17: 5740-3. PMID: 17869104
- Actions of kurtoxin on tetrodotoxin-sensitive voltage-gated Na+ currents, NaV1.6, in murine vas deferens myocytes. | Zhu, HL., et al. 2009. Naunyn Schmiedebergs Arch Pharmacol. 379: 453-60. PMID: 19127357
- Expression and characterization of recombinant kurtoxin, an inhibitor of T-type voltage-gated calcium channels. | Lee, CW., et al. 2011. Biochem Biophys Res Commun. 416: 277-82. PMID: 22093820
- Solution structure of kurtoxin: a gating modifier selective for Cav3 voltage-gated Ca(2+) channels. | Lee, CW., et al. 2012. Biochemistry. 51: 1862-73. PMID: 22329781
- Voltage-activated Ca(2+) channels in rat renal afferent and efferent myocytes: no evidence for the T-type Ca(2+) current. | Smirnov, SV., et al. 2013. Cardiovasc Res. 97: 293-301. PMID: 23042470
- Identification of L- and T-type Ca2+ channels in rat cerebral arteries: role in myogenic tone development. | Abd El-Rahman, RR., et al. 2013. Am J Physiol Heart Circ Physiol. 304: H58-71. PMID: 23103495
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Kurtoxin, 100 µg | sc-300858 | 100 µg | $334.00 |