Molecular structure of KT5823, CAS Number: 126643376
KT5823 (CAS 126643-37-6)
See product citations (21)
Alternate Names:
KT-5823
Application:
KT5823 is a selective inhibitor of cGKI and spontaneous apoptosis
CAS Number:
126643-37-6
Purity:
≥97%
Molecular Weight:
495.50
Molecular Formula:
C29H25N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
KT5823 is a derivative of K-252a (sc-200517) and a selective inhibitor of cGMP-dependent protein kinases (cGKI, Ki=2.4nM) in vitro, but does not inhibit cGMP-dependent protein kinase phosphorylation of VASP in either intact platelets or rat mesangial cells. KT5823 has also been shown to dose-dependently inhibit spontaneous apoptosis of neutrophils, thus suggesting cGK as a mediator of neutrophil spontaneous apoptosis.
KT5823 (CAS 126643-37-6) References
- KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. | Burkhardt, M., et al. 2000. J Biol Chem. 275: 33536-41. PMID: 10922374
- Inhibition of cGMP-dependent protein kinases potently decreases neutrophil spontaneous apoptosis. | Brunetti, M., et al. 2002. Biochem Biophys Res Commun. 297: 498-501. PMID: 12270121
- Inhibition of histamine H1 receptor downregulation by KT5823, a protein kinase G inhibitor. | Miyoshi, K., et al. 2003. Methods Find Exp Clin Pharmacol. 25: 343-7. PMID: 12851655
- Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. | Chan, SL. and Fiscus, RR. 2003. Mol Hum Reprod. 9: 775-83. PMID: 14614039
- Signaling in the mammalian circadian clock: the NO/cGMP pathway. | Golombek, DA., et al. 2004. Neurochem Int. 45: 929-36. PMID: 15312987
- KT5823 activates human neutrophils and fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin. | Wyatt, TA., et al. 1991. Res Commun Chem Pathol Pharmacol. 74: 3-14. PMID: 1666198
- KT5823 differentially modulates sodium iodide symporter expression, activity, and glycosylation between thyroid and breast cancer cells. | Beyer, S., et al. 2011. Endocrinology. 152: 782-92. PMID: 21209020
- K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. | Kase, H., et al. 1987. Biochem Biophys Res Commun. 142: 436-40. PMID: 3028414
- Decorin Protects Cardiac Myocytes against Simulated Ischemia/Reperfusion Injury. | Gáspár, R., et al. 2020. Molecules. 25: PMID: 32731559
- Potential and limitations of PKA/ PKG inhibitors for platelet studies. | Shpakova, V., et al. 2022. Platelets. 33: 859-868. PMID: 34845961
- Regulation of cardiac ryanodine receptor function by the cyclic-GMP dependent protein kinase G. | Gonano, LA., et al. 2022. Curr Res Physiol. 5: 171-178. PMID: 35356048
- C-Type Natriuretic Peptide Regulates the Expression and Secretion of Antibacterial Peptide S100A7 in Goat Mammary Gland Through PKG/JNK/c-Jun Signaling Pathway. | Fan, M., et al. 2022. Front Vet Sci. 9: 822165. PMID: 35498722
- Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. | Hidaka, H., et al. 1984. Biochemistry. 23: 5036-41. PMID: 6238627
Inhibitor of:
ACRC, AKAP 3, Apoptosis, C1orf201, C20orf152, cGKI, cGKI alpha, CRISP-2, GC kinase, Guanylate Cyclase (GUCA), MYLPF, NHE-2, Olfr438, Olfr907, Olfr993, Olfr994, Olfr995, Olfr996, Olfr998, PKA Iα reg, PKA Iβ, PKA IIα reg, PKAβ cat, Tropomyosin, and Vmn2r38.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KT5823, 100 µg | sc-3534 | 100 µg | $182.00 | |||
KT5823, 1 mg | sc-3534A | 1 mg | $1228.00 | |||
KT5823, 5 mg | sc-3534B | 5 mg | $4895.00 |