KSHV ORF 45 Antibody (2D4A5): sc-53883

KSHV ORF 45 Antibody (2D4A5) is a mouse monoclonal IgG1 kappa light chain antibody that detects the KSHV ORF 45 protein of KSHV origin by western blotting (WB) and immunoprecipitation (IP). KSHV ORF 45 (2D4A5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KSHV ORF 45 protein plays a crucial role in the viral life cycle by acting as a viral anti-apoptotic factor, which helps KSHV evade the host′s immune response and promotes the survival of infected cells. This function is particularly important as KSHV persists in the host, contributing to the development of associated diseases such as Kaposi′s sarcoma and lymphoproliferative disorders, especially in immunocompromised individuals. KSHV ORF 45 protein′s ability to inhibit apoptosis not only aids in viral replication but also enhances the oncogenic potential of KSHV, particularly in the context of co-infection with HIV-1, where KSHV ORF 45 can interact with the HIV-1 trans-activating protein (HIV-1 Tat) to further promote oncogenesis. Anti-KSHV ORF 45 antibody (2D4A5) is an essential tool for researchers studying the mechanisms of KSHV pathogenesis and its interactions with host cellular processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

KSHV ORF 45 Antibody (2D4A5) References:

1. Detection of Kaposi's sarcoma herpesvirus DNA sequences in multiple myeloma bone marrow stromal cells.  |  Chauhan, D., et al. 1999. Blood. 93: 1482-6. PMID: 10029574
2. Bone marrow and peripheral blood dendritic cells from patients with multiple myeloma are phenotypically and functionally normal despite the detection of Kaposi's sarcoma herpesvirus gene sequences.  |  Raje, N., et al. 1999. Blood. 93: 1487-95. PMID: 10029575
3. Kaposi's sarcoma-associated herpesvirus gene sequences are detectable at low copy number in primary amyloidosis.  |  Raje, N., et al. 2000. Amyloid. 7: 126-32. PMID: 10842716
4. The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity.  |  Park, J., et al. 2000. J Virol. 74: 11977-82. PMID: 11090200
5. Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus.  |  Grundhoff, A. and Ganem, D. 2001. J Virol. 75: 1857-63. PMID: 11160684
6. Transcription mapping and expression patterns of genes in the major immediate-early region of Kaposi's sarcoma-associated herpesvirus.  |  Saveliev, A., et al. 2002. Virology. 299: 301-14. PMID: 12202233
7. The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions.  |  Zhu, FX. and Yuan, Y. 2003. J Virol. 77: 4221-30. PMID: 12634379
8. bZIP proteins of human gammaherpesviruses.  |  Sinclair, AJ. 2003. J Gen Virol. 84: 1941-1949. PMID: 12867624
9. HHV-8 (KSHV) does not establish latency in prostate cancer cell lines.  |  Munker, R., et al. 1997. Prostate. 33: 286-8. PMID: 9397202

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KSHV ORF 45 Antibody (2D4A5) has 31 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KSHV ORF 45 Antibody (2D4A5) Specifications

Alternate Product Name: KSHV ORF 45

Product Clone Name: 2D4A5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: KSHV ORF 45

Epitope Species: KSHV

Product Reactivity/Detection: Kaposi′s sarcoma-associated herpes virus (KSHV) ORF 45

Species Reactivity/Detection: KSHV

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 31 citations in various scientific publications

Available Conjugates/Forms for KSHV ORF 45 Antibody (2D4A5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin