Krs-2 Antibody (H-8): sc-515051

Krs-2 Antibody (H-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects Krs-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Krs-2 (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Krs-2, also known as MST-1, plays a crucial role in cellular signaling pathways, particularly in activating mitogen-activated protein kinase (MAPK) cascade, which regulates cellular processes like proliferation, differentiation, and apoptosis. Krs-2 functions as a direct substrate of caspase-3, participating in apoptotic signaling pathways that influence cell survival and death. Krs-2′s ability to modulate these pathways underscores its significance in normal physiological processes and diseases like cancer, where dysregulation of apoptosis can lead to tumorigenesis. Using anti-Krs-2 antibody (H-8) enables researchers to gain valuable insights into this protein′s functional dynamics and biological implications.

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Krs-2 Antibody (H-8) References:

1. Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase.  |  Zhou, TH., et al. 2000. J Biol Chem. 275: 2513-9. PMID: 10644707
2. Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway.  |  Raitt, DC., et al. 2000. EMBO J. 19: 4623-31. PMID: 10970855
3. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.  |  Lee, KK., et al. 2001. J Biol Chem. 276: 19276-85. PMID: 11278283
4. MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway.  |  Lin, JL., et al. 2001. Oncogene. 20: 6559-69. PMID: 11641781
5. The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.  |  Leberer, E., et al. 1992. EMBO J. 11: 4815-24. PMID: 1464311
6. AIF downregulation and its interaction with STK3 in renal cell carcinoma.  |  Xu, S., et al. 2014. PLoS One. 9: e100824. PMID: 24992339
7. Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy.  |  Wilkinson, DS., et al. 2015. Mol Cell. 57: 55-68. PMID: 25544559
8. STK3/STK4 signalling in adipocytes regulates mitophagy and energy expenditure.  |  Cho, YK., et al. 2021. Nat Metab. 3: 428-441. PMID: 33758424
9. Serine/Threonine Protein Kinase-3 Promotes Oral Squamous Cell Carcinoma by Activating Ras-MAPK Mediated Cell Cycle Progression.  |  Yue, L., et al. 2023. Int J Gen Med. 16: 3115-3124. PMID: 37496599
10. STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma.  |  Zhao, Z., et al. 2024. Cell Oncol (Dordr). 47: 1295-1314. PMID: 38436783
11. Exploring STK3 in melanoma: a systematic review of signaling networks and therapeutic opportunities.  |  Khanahmadi, M., et al. 2024. Mol Biol Rep. 52: 8. PMID: 39576434
12. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements.  |  Schinkmann, K. and Blenis, J. 1997. J Biol Chem. 272: 28695-703. PMID: 9353338

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Krs-2 Antibody (H-8) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Krs-2 Antibody (H-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Krs-2 Antibody (H-8) Specifications

Alternate Product Name: Krs-2

Product Clone Name: H-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 291-355

Epitope Target: Krs-2

Epitope Species: human

Product Reactivity/Detection: Krs-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Krs-2 Antibody (H-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin