KNRK Whole Cell Lysate: sc-2214

KNRK Whole Cell Lysate is derived from the KNRK cell line, which originates from rat kidney cells transformed by the Kirsten murine sarcoma virus. This transformation equips the cells with oncogenic properties, mainly through the activation of the Kirsten rat sarcoma (KRAS) viral oncogene. The whole cell lysate from KNRK cells provides a broad spectrum of cellular components, including proteins, RNA, DNA, and various metabolites, representing the full cellular environment influenced by the KRAS oncogene. This lysate is extensively used in research focusing on the role of KRAS in cell signaling and oncogenesis. By studying KNRK Whole Cell Lysate, researchers can delve into the molecular mechanisms by which KRAS mutations lead to altered cell signaling pathways, particularly those related to cell growth, differentiation, and survival. The lysate serves as a critical tool for scientists investigating the downstream effects of KRAS activation, such as the activation of MAPK and PI3K pathways, which are pivotal in understanding the cellular adaptations in oncogene-driven cancers. Moreover, it aids in the study of interactions between oncogenic signaling and other cellular processes, contributing valuable insights into the complexity of cancer biology and the cellular impact of specific genetic alterations.

KNRK Whole Cell Lysate References:

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6. AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats.  |  Zhou, J., et al. 2006. Stroke. 37: 1271-6. PMID: 16601219
7. Angiotensin II induced contraction of rat and human small intestinal wall musculature in vitro.  |  Ewert, S., et al. 2006. Acta Physiol (Oxf). 188: 33-40. PMID: 16911251
8. MARCKS dephosphorylation is involved in bradykinin-induced neurite outgrowth in neuroblastoma SH-SY5Y cells.  |  Tanabe, A., et al. 2012. J Cell Physiol. 227: 618-29. PMID: 21448919
9. Blueprint of an ancestral neurosensory organ revealed in glial networks in human dental pulp.  |  Farahani, RM., et al. 2011. J Comp Neurol. 519: 3306-26. PMID: 21681747
10. Differential expression of components of the retinoic acid signaling pathway in the adult mouse olfactory epithelium.  |  Peluso, CE., et al. 2012. J Comp Neurol. 520: 3707-26. PMID: 22522724
11. Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants.  |  Mietzsch, U., et al. 2013. J Comp Neurol. 521: 3817-31. PMID: 23749404
12. Modulation of ENaC, CFTR, and iNOS expression in bronchial epithelial cells after stimulation with Staphylococcus epidermidis (94B080) and Staphylococcus aureus (90B083).  |  Hussain, R., et al. 2013. APMIS. 121: 814-26. PMID: 23879620
13. Immunoselection of GRP94/endoplasmin from a KNRK cell-specific lambda gt11 library using antibodies directed against a putative heparanase amino-terminal peptide.  |  De Vouge, MW., et al. 1994. Int J Cancer. 56: 286-94. PMID: 8314313