Molecular structure of KN-92, CAS Number: 1135280-28-2
KN-92 (CAS 1135280-28-2)
See product citations (7)
Alternate Names:
2-[N-(4-Methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine, Phosphate
Application:
KN-92 is a useful negative control for KN-93
CAS Number:
1135280-28-2
Purity:
≥95%
Molecular Weight:
555.0
Molecular Formula:
C24H25ClN2O3S•H3PO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
KN-92 is the inactive form of KN-93 (sc-202199). KN-93 is a methoxybenzenesulfonamide that is an effective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) phosphorylating activity, and the autophosphorylation of the α- and β-subunits of CaMKII. KN-92 has been used to study CaMKII inhibitors and GluA1 AMPA receptors.
KN-92 (CAS 1135280-28-2) References
- KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels. | Rezazadeh, S., et al. 2006. J Pharmacol Exp Ther. 317: 292-9. PMID: 16368898
- The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. | Sumi, M., et al. 1991. Biochem Biophys Res Commun. 181: 968-75. PMID: 1662507
- KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. | An, P., et al. 2007. World J Gastroenterol. 13: 1445-8. PMID: 17457979
- Ca2+/calmodulin-dependent protein kinase II inhibitors disrupt AKAP79-dependent PKC signaling to GluA1 AMPA receptors. | Brooks, IM. and Tavalin, SJ. 2011. J Biol Chem. 286: 6697-706. PMID: 21156788
- Beta Ca2+/CaM-dependent kinase type II triggers upregulation of GluA1 to coordinate adaptation to synaptic inactivity in hippocampal neurons. | Groth, RD., et al. 2011. Proc Natl Acad Sci U S A. 108: 828-33. PMID: 21187407
- Effects of calmodulin-dependent protein kinase II inhibitor, KN-93, on electrophysiological features of rabbit hypertrophic cardiac myocytes. | Ke, J., et al. 2012. J Huazhong Univ Sci Technolog Med Sci. 32: 485-489. PMID: 22886958
- Effects of isoquinolonesulfonamides on action potential secretion coupling in pituitary cells. | Popovic, MA., et al. 2010. Horm Mol Biol Clin Investig. 1: 35-42. PMID: 25961970
- Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner. | Takeuchi, M. and Yamamoto, T. 2015. Exp Cell Res. 335: 62-7. PMID: 26024774
- Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine. | Zhang, X., et al. 2018. Front Pharmacol. 9: 166. PMID: 29545750
- Chronic Ca2+/Calmodulin-Dependent Protein Kinase II Inhibition Rescues Advanced Heart Failure. | Liu, Y., et al. 2021. J Pharmacol Exp Ther. 377: 316-325. PMID: 33722881
- Modulation by calcium/calmodulin-dependent protein kinase II of functional response of delta opioid receptor in neuroblastoma x glioma hybrid (NG108-15) cells. | Fan, GH., et al. 1997. Neuropharmacology. 36: 1763-9. PMID: 9517449
Inhibitor of:
CaMKI, CaMKIIα, CaMKIIδ, and SLMAP.Activator of:
CaMKKα.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KN-92, 1 mg | sc-311369 | 1 mg | $182.00 | |||
KN-92, 5 mg | sc-311369A | 5 mg | $561.00 |