KLK10 Antibody (I-06): sc-100551

KLK10 Antibody (I-06) is a mouse monoclonal IgG1 antibody that detects KLK10 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KLK10 antibody (I-06) is available as the non-conjugated format. KLK10 protein is part of the kallikrein family, which consists of serine proteases that play crucial roles in various physiological processes, including blood pressure regulation, inflammation, and tissue remodeling. KLK10 has been implicated in cancer development, as expression levels can be altered in malignant tissues. KLK10 protein is primarily located in prostate and breast tissues, where KLK10 contributes to proteolytic processing of extracellular matrix components, influencing tumor progression and metastasis. Understanding KLK10 localization and function is essential for elucidating KLK10′s role in cancer biology and developing potential therapeutic strategies. The human KLK gene family, which includes 15 members, is clustered on chromosome 19q13, and many genes are regulated by steroid hormones, highlighting their importance in hormone-related cancers. KLK10 protein, along with other kallikreins, is being studied as a potential biomarker in cancer diagnostics, particularly in prostate and breast cancer, where KLK10 expression may provide insights into disease progression and treatment response.

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KLK10 Antibody (I-06) References:

1. The new human kallikrein gene family: implications in carcinogenesis.  |  Diamandis, EP., et al. 2000. Trends Endocrinol Metab. 11: 54-60. PMID: 10675891
2. Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4.  |  Yousef, GM., et al. 2000. Biochem Biophys Res Commun. 276: 125-33. PMID: 11006094
3. Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer.  |  Yousef, GM., et al. 2001. J Biol Chem. 276: 53-61. PMID: 11010966
4. The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions.  |  Clements, J., et al. 2001. Biol Chem. 382: 5-14. PMID: 11258672
5. Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies.  |  Yousef, GM., et al. 2001. Cancer Res. 61: 3425-31. PMID: 11309303
6. Expression of the kallikrein gene family in normal and Alzheimer's disease brain.  |  Shimizu-Okabe, C., et al. 2001. Neuroreport. 12: 2747-51. PMID: 11522960
7. NES1/KLK10 promotes trastuzumab resistance via activation of PI3K/AKT signaling pathway in gastric cancer.  |  Tang, L., et al. 2018. J Cell Biochem. 119: 6398-6407. PMID: 29231994
8. The Role of Kallikrein10 (KLK10) Polymorphism in Prostate Cancer Susceptibility.  |  Güleç Yılmaz, S., et al. 2021. Urol J. 19: 41-44. PMID: 34089177
9. Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis.  |  Williams, D., et al. 2022. Elife. 11: PMID: 35014606
10. KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.  |  Wu, K., et al. 2024. Cell Biol Int. 48: 440-449. PMID: 38115179
11. KLK10/LIPH/PARD6B/SLC52A3 are promising molecular biomarkers for the prognosis of pancreatic cancer through a ceRNA network.  |  Zhang, M., et al. 2024. Heliyon. 10: e24287. PMID: 38234923
12. KLK10 derived from tumor endothelial cells accelerates colon cancer cell proliferation and hematogenous liver metastasis formation.  |  Kato, K., et al. 2024. Cancer Sci. 115: 1520-1535. PMID: 38475666

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KLK10 Antibody (I-06) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-KLK10 Antibody (I-06) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KLK10 Antibody (I-06) Specifications

Alternate Product Name: KLK10

Product Clone Name: I-06

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ lambda light chain

Amino Acids: 167-277

Epitope Target: KLK10

Epitope Species: human

Product Reactivity/Detection: KLK10

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 50 µg IgG₁ lambda light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for KLK10 Antibody (I-06): N/A