Kisspeptin-234 trifluoroacetate salt (CAS 1848962-29-7)
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Kisspeptin-234 is a 10-amino acid peptide antagonist with potent neutral antagonist activity at GPR-54 and competes directly at the Kisspeptin-10 binding site. Kisspeptin-234 is the first reported antagonist for the kisspeptin-1/GPR-54 signaling system. Kisspeptins, as a family, are peptides that play a pivotal role in the regulation of the gonadotropin-releasing hormone (GnRH). The chemical stability and bioactivity provided by the trifluoroacetate salt make it particularly suitable for in vitro studies. Trifluoroacetate counterions are often used to improve peptide solubility and stability. Kisspeptin-234 trifluoroacetate salt can be used as a tool to dissect the molecular mechanisms underlying GnRH secretion and the complex feedback loops that regulate reproductive hormones. Its application in this field could lead to the development of novel assays and models for studying hormonal pathways.
Kisspeptin-234 trifluoroacetate salt (CAS 1848962-29-7) References
- Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. | Roseweir, AK., et al. 2009. J Neurosci. 29: 3920-9. PMID: 19321788
- Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism. | Fu, LY. and van den Pol, AN. 2010. J Neurosci. 30: 10205-19. PMID: 20668204
- Modulation of testicular and whole blood trace element concentrations in conjunction with testosterone release following kisspeptin administration in male rabbits (Oryctolagus cuniculus). | Qureshi, IZ. and Abbas, Q. 2013. Biol Trace Elem Res. 154: 210-6. PMID: 23812650
- Relationships between leptin, KiSS-1/GPR54 expression and TSH secretion from pituitary cells of pubertal ewes in vitro. | Radwańska, P. and Kosior-Korzecka, U. 2016. Res Vet Sci. 105: 180-7. PMID: 27033929
- Recombinant Lactococcus lactis NZ9000 secretes a bioactive kisspeptin that inhibits proliferation and migration of human colon carcinoma HT-29 cells. | Zhang, B., et al. 2016. Microb Cell Fact. 15: 102. PMID: 27287327
- The ontogeny of kisspeptin receptor in the uterine contractions in rats: Its possible role in the quiescence of non-pregnant and pregnant uteri. | Schaffer, A., et al. 2021. Eur J Pharmacol. 896: 173924. PMID: 33548216
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Kisspeptin-234 trifluoroacetate salt, 1 mg | sc-300857 | 1 mg | $184.00 |