Kinectin 1 Antibody (A-12): sc-374577

Kinectin 1 Antibody (A-12) is a mouse monoclonal IgG3 kappa light chain antibody that detects Kinectin 1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Kinectin 1 antibody (A-12) is available as a non-conjugated format. Kinectin 1, also referred to as kinesin receptor, is an integral membrane protein located in the endoplasmic reticulum (ER), playing a crucial role in the transport of vesicles along microtubules. Strategic positioning within the ER is vital for facilitating the interaction between kinesin motor proteins and their cargo, ensuring efficient intracellular transport. Proper functioning of Kinectin 1 is essential for maintaining cellular homeostasis and supporting various cellular processes, including the distribution of organelles and signaling molecules. Disruptions in Kinectin 1 function can lead to impaired vesicle transport, which has been implicated in several neurodegenerative diseases. Using Kinectin 1 (A-12) antibody in research can provide valuable insights into the mechanisms of intracellular transport and the potential pathological consequences of dysregulation.

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Kinectin 1 Antibody (A-12) References:

1. Defective kinesin heavy chain behavior in mouse kinesin light chain mutants.  |  Rahman, A., et al. 1999. J Cell Biol. 146: 1277-88. PMID: 10491391
2. Kinesin and kinectin can associate with the melanosomal surface and form a link with microtubules in normal human melanocytes.  |  Vancoillie, G., et al. 2000. J Invest Dermatol. 114: 421-9. PMID: 10692099
3. Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence.  |  Luo, X., et al. 2021. Addict Biol. 26: e12888. PMID: 32115811
4. KTN1 variants and risk for attention deficit hyperactivity disorder.  |  Luo, X., et al. 2020. Am J Med Genet B Neuropsychiatr Genet. 183: 234-244. PMID: 32190980
5. Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum.  |  Guadagno, NA., et al. 2020. J Cell Biol. 219: PMID: 32525992
6. Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity.  |  Gao, L., et al. 2021. Signal Transduct Target Ther. 6: 250. PMID: 34219129
7. Upregulating KTN1 promotes Hepatocellular Carcinoma progression.  |  Pan, J., et al. 2021. J Cancer. 12: 4791-4809. PMID: 34234850
8. A significant, functional and replicable risk KTN1 variant block for schizophrenia.  |  Mao, Q., et al. 2023. Sci Rep. 13: 3890. PMID: 36890161
9. Kinectin, an essential anchor for kinesin-driven vesicle motility.  |  Kumar, J., et al. 1995. Science. 267: 1834-7. PMID: 7892610
10. Expression of neuronal kinesin heavy chain is developmentally regulated in the central nervous system of the rat.  |  Vignali, G., et al. 1997. J Neurochem. 69: 1840-9. PMID: 9349526
11. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins.  |  Rahman, A., et al. 1998. J Biol Chem. 273: 15395-403. PMID: 9624122
12. The C-terminal region of the stalk domain of ubiquitous human kinesin heavy chain contains the binding site for kinesin light chain.  |  Diefenbach, RJ., et al. 1998. Biochemistry. 37: 16663-70. PMID: 9843434

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Kinectin 1 Antibody (A-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Kinectin 1 Antibody (A-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Kinectin 1 Antibody (A-12) Specifications

Alternate Product Name: Kinectin 1

Product Clone Name: A-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 1156-1345

Epitope Target: Kinectin 1

Epitope Species: human

Product Reactivity/Detection: Kinectin 1 isoforms 1 and 2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Kinectin 1 Antibody (A-12): N/A