Kigamicin C CAS: 680571-51-1
MF: C41H47NO16
MW: 809.81
A novel antibiotic antiproliferative with novel action.

Kigamicin C (CAS 680571-51-1)

Kigamicin C | CAS 680571-51-1 is rated 5.0 out of 5 by 1.
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Application: Kigamicin C is a novel antibiotic antiproliferative with novel action
CAS Number: 680571-51-1
Purity: ≥97%
Molecular Weight: 809.81
Molecular Formula: C41H47NO16
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Kigamicin C is a member of the kigamicin antibiotics isolated from Amycolatopsis culture broths, with antimicrobial and antiproliferative properties. The kigamicins demonstrate growth inhibition of methicillin-resistant Staphylococcus aureus strains, are active against gram-positive bacteria, and inactive against gram-negative bacteria. Kigamicin C and other kigamicins demonstrate cytotoxicity against PANC-1 pancreatic cancer cells under nutrient starved conditions, requiring a markedly lower concentration (~100-fold) of kigamicin to inhibit growth of PANC-1 cells under nutrient-starved conditions than under nutrient-rich conditions. It is proposed that the kigamicins block the activation of PKB/Akt signaled by PANC-1 cells in response to a nutrient-deprived state, disturbing a potential mechanism of cancer starvation resistance. Extending these observations, Kigamicin D (representing the kigamicin family) is specifically show to suppress an activating phosphorylation of Akt presented by cells in response to a nutrient-starved growth medium. Kigamicin C and the kigamicins (named for kiga, a japanese word for starvation) present a novel intervention upon the resistance to nutrient starvation characteristic of oncogenesis.


References

1. Kunimoto, S., et al. 2003. J. Antibiot. 56: 1004-1011. PMID: 15015727
2. Kunimoto, S., et al. 2003. J. Antibiot. 56: 1012-1017. PMID: 15015728
3. Lu, J., et al. 2004. Cancer Sci. 95: 547-552. PMID: 15182438
4. Nakamura, M., et al. 2008. Anticancer Res. 28: 37-43. PMID: 18383822

Physical State :
Solid
Derived From :
Amycolatopsis sp.
Solubility :
Soluble in ethanol, methanol, DMSO, and DMF.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
COC1CC(OC2CCC(OC2C)OC2CC(O)c3c(oc4c5OCOC6Cc7cc8CC9(C)OCCN9C(=O)c8c(O)c7c(c56)c(O)c4c3=O)C2O)OC(C)C1O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Nakamura et al Nakamura et al. (PubMed ID 18383822) found that kigamicin A activated necrosis in myeloma cells by inhibiting cyclin D1, p21, p-AKT and p-ERK. -SCBT Publication Review
Date published: 2015-01-06
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