KIF21B Antibody (4C12): sc-517174

KIF21B Antibody (4C12) is a mouse monoclonal IgG2a kappa light chain antibody that detects KIF21B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-KIF21B antibody (4C12) is available as a non-conjugated format. KIF21B, or kinesin family member 21B, is a vital protein consisting of 1,637 amino acids, featuring a kinesin-motor domain that facilitates ATP-dependent movement along microtubules, as well as seven WD repeats that are thought to play a role in cargo binding. KIF21B protein is predominantly localized in dendrites, underscoring its critical function in neuronal dendritic transport, which is essential for the proper functioning of neurons and the overall health of the nervous system. The transport of organelles and signaling molecules within dendrites is crucial for synaptic plasticity and communication between neurons, making KIF21B integral to processes such as learning and memory. The gene encoding human KIF21B is located on chromosome 1, the largest human chromosome, which spans approximately 260 million base pairs and constitutes about 8% of the human genome.

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KIF21B Antibody (4C12) References:

1. Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B.  |  Marszalek, JR., et al. 1999. J Cell Biol. 145: 469-79. PMID: 10225949
2. All kinesin superfamily protein, KIF, genes in mouse and human.  |  Miki, H., et al. 2001. Proc Natl Acad Sci U S A. 98: 7004-11. PMID: 11416179
3. A kinesin medley: biochemical and functional heterogeneity.  |  Brady, ST. 1995. Trends Cell Biol. 5: 159-64. PMID: 14732151
4. New insights into the evolution of chromosome 1.  |  Weise, A., et al. 2005. Cytogenet Genome Res. 108: 217-22. PMID: 15545733
5. Chromosome 1 abnormalities in multiple myeloma.  |  Marzin, Y., et al. 2006. Anticancer Res. 26: 953-9. PMID: 16619492
6. The DNA sequence and biological annotation of human chromosome 1.  |  Gregory, SG., et al. 2006. Nature. 441: 315-21. PMID: 16710414
7. The emerging kinesin family of microtubule motor proteins.  |  Endow, SA. 1991. Trends Biochem Sci. 16: 221-5. PMID: 1832505
8. Motor proteins of cytoplasmic microtubules.  |  Vallee, RB. and Shpetner, HS. 1990. Annu Rev Biochem. 59: 909-32. PMID: 2142876

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KIF21B Antibody (4C12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-KIF21B Antibody (4C12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KIF21B Antibody (4C12) Specifications

Alternate Product Name: KIF21B

Product Clone Name: 4C12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1183-1282

Epitope Target: KIF21B

Epitope Species: human

Product Reactivity/Detection: KIF21B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for KIF21B Antibody (4C12): N/A