KIF13B Antibody (6E11): sc-517181

KIF13B Antibody (6E11) is a mouse monoclonal IgG2a kappa light chain antibody that detects KIF13B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-KIF13B antibody (6E11) is available as a non-conjugated format. KIF13B, also known as kinesin family member 13B or GAKIN, is a crucial 1,826 amino acid protein that plays a significant role in intracellular transport, particularly in the brain and kidney where expression is highest. KIF13B is primarily localized in the cytoplasm and associated with the cytoskeleton, functioning as a microtubule-dependent motor protein that facilitates movement of various cellular components to designated locations. KIF13B belongs to the kinesin-like protein family and features three characteristic domains: an N-terminal motor domain with an ATP-binding motif, an FHA domain that binds diverse cargo, and a large stalk domain that mediates protein-protein interactions. KIF13B contains a highly conserved CAP-Gly domain at its C-terminus, which is essential for microtubule interaction. Defects in this domain have been linked to various diseases that disrupt vesicle trafficking, neuromuscular junction integrity, and lysosomal function, highlighting KIF13B′s importance in maintaining cellular homeostasis and proper physiological function.

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KIF13B Antibody (6E11) References:

1. GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes.  |  Hanada, T., et al. 2000. J Biol Chem. 275: 28774-84. PMID: 10859302
2. Direct interaction with a kinesin-related motor mediates transport of mammalian discs large tumor suppressor homologue in epithelial cells.  |  Asaba, N., et al. 2003. J Biol Chem. 278: 8395-400. PMID: 12496241
3. Centaurin-alpha1 interacts directly with kinesin motor protein KIF13B.  |  Venkateswarlu, K., et al. 2005. J Cell Sci. 118: 2471-84. PMID: 15923660
4. Centaurin-alpha1 and KIF13B kinesin motor protein interaction in ARF6 signalling.  |  Kanamarlapudi, V. 2005. Biochem Soc Trans. 33: 1279-81. PMID: 16246098
5. Transport of PIP3 by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity.  |  Horiguchi, K., et al. 2006. J Cell Biol. 174: 425-36. PMID: 16864656
6. The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B.  |  Yamada, KH., et al. 2007. Biochemistry. 46: 10039-45. PMID: 17696365
7. Functional involvement of human discs large tumor suppressor in cytokinesis.  |  Unno, K., et al. 2008. Exp Cell Res. 314: 3118-29. PMID: 18760273
8. Capturing protein tails by CAP-Gly domains.  |  Steinmetz, MO. and Akhmanova, A. 2008. Trends Biochem Sci. 33: 535-45. PMID: 18835717

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KIF13B Antibody (6E11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-KIF13B Antibody (6E11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KIF13B Antibody (6E11) Specifications

Alternate Product Name: KIF13B

Product Clone Name: 6E11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-100

Epitope Target: KIF13B

Epitope Species: human

Product Reactivity/Detection: KIF13B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for KIF13B Antibody (6E11): N/A